Title:
COMPOUND HAVING TYROSINE PROTEIN KINASE JAK1- OR JAK2-INHIBITTION AND DEGRADATION ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/042442
Kind Code:
A1
Abstract:
The present invention provides a compound having tyrosine protein kinase JAK1- or JAK2-inhibittion and degradation activity. Specifically, the present invention provides a compound as represented by the following formula I, wherein the definition of each group is as stated in the description. The compound provided by the present invention has excellent JAK1- or JAK2-inhibittion and degradation activity, and can be used for preparing drugs for treatment of JAK1- or JAK2-related diseases.
Inventors:
SHU YONGZHI (CN)
Application Number:
PCT/CN2018/103707
Publication Date:
March 07, 2019
Filing Date:
September 02, 2018
Export Citation:
Assignee:
SHANGHAI MEIZER PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P1/00; A61P1/04; A61P3/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/28; A61P35/00; A61P37/06
Domestic Patent References:
| WO2015038649A1 | 2015-03-19 |
Foreign References:
| US9464088B2 | 2016-10-11 | |||
| CN106336413A | 2017-01-18 | |||
| CN106432246A | 2017-02-22 |
Other References:
ZHOU, BING ET AL.: "Discovery of a Small-Molecule Degrader of Bromodomain and Extra- Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression", J. MED. CHEM., vol. 61, no. 2, 24 March 2017 (2017-03-24), XP055387473, ISSN: 0022-2623
Attorney, Agent or Firm:
DEHEHANTONG LAW FIRM (CN)
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