Title:
COMPOUND FOR IMPROVING CELL TRANSPLANTATION EFFICIENCY
Document Type and Number:
WIPO Patent Application WO/2019/181901
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound that acts to inhibit anoikis in cells and enhance cell survival rates, and a compound that induces cell infiltration and enhances cell engraftment. The present invention provides a compound represented by formula (I) or a salt thereof. [In the formula, ring A1 and ring A2 are the same or different and represent a substitutable six-membered aromatic heterocyclic group having 1–3 nitrogen atoms, R1 represents formyl or hydroxymethyl, and R2 is a group represented by -L-(X1)n-(X2)m-(X3)p-NH2 (in the formula: L represents a linker; n represents 0, 1, or 2; m represents 2 or 3; p represents 0, 1, 2, or 3; X1 and X3 each independently represent an amino acid residue selected from among Ser, Ala, Gly, Lys, Val, Leu, Ile, Thr, Cys, Met, Asn, Gln, Pro, Asp, Glu, Arg, His, and Orn; and the X2 radicals are the same or different and represent an amino acid residue selected from among Phe, Tyr, and Trp).]
Inventors:
UESUGI MOTONARI (JP)
TAKASHIMA IPPEI (JP)
NISHIKAWA MAKIYA (JP)
TAKASHIMA IPPEI (JP)
NISHIKAWA MAKIYA (JP)
Application Number:
PCT/JP2019/011320
Publication Date:
September 26, 2019
Filing Date:
March 19, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV TOKYO SCIENCE FOUND (JP)
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
C07K5/04; A61K47/64; C07K7/06; C12N1/00; A61K35/12
Domestic Patent References:
| WO2013168807A1 | 2013-11-14 | |||
| WO2009154201A1 | 2009-12-23 |
Other References:
FRISCO-CABANOS, H. L. ET AL.: "Synthetic molecules that protect cells from anoikis and their use in cell transplantation", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 53, no. 42, 2014, pages 11208 - 11213, XP055637531
SCHMIDTKE, M. ET AL.: "Synthesis, cytotoxicity and antiviral activity of N,N'-bis-5-nitropyrimidyl derivatives of dispirotripiperazine", ANTIVIRAL RESEARCH, vol. 55, 2002, pages 117 - 127, XP008141707
TAKASHIMA, I. ET AL.: "Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment", ACS CHEMICAL BIOLOGY, vol. 14, no. 4, 26 February 2019 (2019-02-26), pages 775 - 783, XP055637536
SCHMIDTKE, M. ET AL.: "Synthesis, cytotoxicity and antiviral activity of N,N'-bis-5-nitropyrimidyl derivatives of dispirotripiperazine", ANTIVIRAL RESEARCH, vol. 55, 2002, pages 117 - 127, XP008141707
TAKASHIMA, I. ET AL.: "Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment", ACS CHEMICAL BIOLOGY, vol. 14, no. 4, 26 February 2019 (2019-02-26), pages 775 - 783, XP055637536
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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