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Title:
COMPOUND FOR INHIBITING IDO, MANUFACTURING METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/184585
Kind Code:
A1
Abstract:
The present invention provides a compound for inhibiting IDO, a manufacturing method and a use thereof. The compound has a general structural formula of (I), wherein (II) is selected from a cis-isomer, a trans-isomer, or a mixture of cis- and trans-isomers; R1 and R2 are each independently selected from any one of H, halogen, an alkyl, alkoxy, or haloalkyl group; R3 is selected from any one of a cyclopentyl, cyclohexyl, piperazinyl, or piperidyl group; substitution positions of R3 are at 1,2-, 1,3- or 1,4-positions; and m and n are respectively an integer from 0 to 5. The compound of the present invention capable of inhibiting IDO has a strong inhibitive effect on IDO and can be used to manufacture an IDO inhibitor for the prevention and/or treatment of a disease characterized by a pathological tryptophan metabolic pathway mediated by IDO. The compound of the present invention has very good application potential.

Inventors:
ZHONG, Yan (Fl 3, Building 1 400 Fang Chun Road, China Pilot Free Trade Zone, Pudong New District, Shanghai 3, 201203, CN)
CAO, Xirong (Fl 3, Building 1 400 Fang Chun Road, China Pilot Free Trade Zone, Pudong New District, Shanghai 3, 201203, CN)
WANG, Yonglin (Fl 3, Building 1 400 Fang Chun Road, China Pilot Free Trade Zone, Pudong New District, Shanghai 3, 201203, CN)
Application Number:
CN2018/082062
Publication Date:
October 11, 2018
Filing Date:
April 05, 2018
Export Citation:
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Assignee:
SHANGHAI JOYU PHARMATECH LTD. (Fl 3, Building 1 400 Fang Chun Road, China Pilot Free Trade Zone, Pudong New District, Shanghai 3, 201203, CN)
International Classes:
C07D271/08; A61K31/4245; A61P25/00; A61P25/22; A61P25/24; A61P25/28; A61P27/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02
Domestic Patent References:
WO2017024996A12017-02-16
WO2016155545A12016-10-06
Foreign References:
CN106967005A2017-07-21
CN107304191A2017-10-31
CN106883194A2017-06-23
CN102164902A2011-08-24
Attorney, Agent or Firm:
SUNSHINEIP INTELLECTUAL PROPERTY LAW FIRM (Room 2103, Jiaxing Building No. 877, Dongfang Road, Pudong New District, Shanghai 2, 200122, CN)
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