COMPOUND LIBRARIES OF 1,3,5-SUBSTITUTE INDAZOLE DERIVATIVES AS COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN COUPLED RECEPTOR

Title:

COMPOUND LIBRARIES OF 1,3,5-SUBSTITUTE INDAZOLE DERIVATIVES AS COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN COUPLED RECEPTOR

Document Type and Number:

WIPO Patent Application WO2004058720

Kind Code:

A3

Abstract:

The present invention provides a compound library that is targeted against a group of peptide liganded receptors, which can be characterised broadly as requiring an interaction with an amide or acid function interacting largely by hydrogen bonding. In addition the library picks up interactions for electron-rich aromatic rings and other interactions. The library comprises or consists of a set of structurally related compounds of general formulae (A), (B) and (C), as well as intermediates of structure (I).

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Inventors:

JONES GRAHAM PETER (GB)
PARSY CHRISTOPHE (FR)
MACRITCHIE JACQUELINE ANNE (GB)

Application Number:

PCT/GB2003/005650

Publication Date:

August 19, 2004

Filing Date:

December 24, 2003

Export Citation:

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Assignee:

BIOFOCUS PLC (GB)
JONES GRAHAM PETER (GB)
PARSY CHRISTOPHE (FR)
MACRITCHIE JACQUELINE ANNE (GB)

International Classes:

A61K31/4184; A61K31/438; A61K31/445; A61K31/4747; C07D241/20; C07D241/24; C07D403/04; C07D403/10; C07D405/10; C07D413/12; C07D471/04; C07D471/10; C07D471/20; C07D491/20; C07B61/00; (IPC1-7): C07D403/10; A61K31/4184; C07B61/00; C07D231/56; C07D405/12; C07D405/14

Domestic Patent References:

WO1999009024A1	1999-02-25
WO1998054116A1	1998-12-03

Other References:

ZHANG ET AL.: "Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates", J. MED. CHEM., vol. 44, 22 March 2001 (2001-03-22), pages 1021 - 1024, XP002279666
PARNELL E W: "2-Cyano-4-nitrophenylhydrazine and 3-Amino-5-nitroindazole", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1959, pages 2363 - 2365, XP002185285, ISSN: 0368-1769
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 27 June 1988 (1988-06-27), XP002279667, Database accession no. BRN 6354
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 27 June 1988 (1988-06-27), XP002279668, Database accession no. BRN 9068
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 28 November 1988 (1988-11-28), XP002279669, Database accession no. BRN 518679
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 28 November 1988 (1988-11-28), XP002279670, Database accession no. BRN 518680
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 28 November 1988 (1988-11-28), XP002279671, Database accession no. BRN 519491
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 28 November 1988 (1988-11-28), XP002279672, Database accession no. BRN 531661
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 27 June 1988 (1988-06-27), XP002279673, Database accession no. BRN 3706

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