Title:
COMPOUND AND LIPID COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/176822
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a sterol compound capable of achieving excellent nucleic acid delivery efficiency when used in lipid compositions; and a lipid composition which is capable of achieving excellent nucleic acid delivery efficiency and contains the sterol compound. According to the present invention, a compound represented by formula (1) is provided. In the formula, R201 represents a cyclic hydrocarbon group optionally substituted with at least one substituent which is a C1-18 hydrocarbon group, R102 represents (i) a hydrogen atom, (ii) a C1-4 hydrocarbon group optionally substituted with at least one substituent selected from OH, SH, COOH, NR106R107, N(R108)C(O)R109, or CF3, (iii) C(O)R103, or (iv) C(O)NR104R105, and the definitions of other symbols are set forth in the specification.
Inventors:
TANABE SHINTARO (JP)
NITABARU TATSUYA (JP)
YOSHIMURA MASASHI (JP)
MAKITA KEIKO (JP)
FUKUNAGA HIROFUMI (JP)
NITABARU TATSUYA (JP)
YOSHIMURA MASASHI (JP)
MAKITA KEIKO (JP)
FUKUNAGA HIROFUMI (JP)
Application Number:
PCT/JP2023/009822
Publication Date:
September 21, 2023
Filing Date:
March 14, 2023
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07J9/00; A61K9/10; A61K31/7088; A61K47/28; A61K48/00; C12N15/88
Domestic Patent References:
| WO2020246581A1 | 2020-12-10 | |||
| WO2021095876A1 | 2021-05-20 |
Foreign References:
| JP2022501348A | 2022-01-06 | |||
| JP2012526858A | 2012-11-01 | |||
| CN112047898A | 2020-12-08 |
Other References:
CLEMENT OMOSHILE O, ET AL: "Three Dimensional Pharmacophore Modeling of Human CYP17 Inhibitors. Potential Agents for Prostate Cancer Therapy", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 46, no. 12, 10 May 2003 (2003-05-10), US , pages 2345 - 2351, XP002535273, ISSN: 0022-2623, DOI: 10.1021/JM020576U
LIU YUEJIN, RONG SHIHONG: "Study on the antitumor activity of hydroxycholanic acid derivatives Synthesis and in vitro antitumor activity of 3β,5α,6β-trihydroxycholanic acid derivatives and 3β,6β-dihydroxychol-4-enic acid derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 6, 2004, pages 344 - 349, XP009548614
XIAOXU QI; PINHONG CHEN; GUOSHENG LIU: "Catalytic Oxidative Trifluoromethoxylation of Allylic C−H Bonds Using a Palladium Catalyst", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 56, no. 32, 6 July 2017 (2017-07-06), Hoboken, USA, pages 9517 - 9521, XP072092992, ISSN: 1433-7851, DOI: 10.1002/anie.201703841
HAODONG YANG; FENG WANG; XIAOHUAN JIANG; YU ZHOU; XIUFANG XU; PINGPING TANG: "Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 57, no. 40, 4 September 2018 (2018-09-04), Hoboken, USA, pages 13266 - 13270, XP072096229, ISSN: 1433-7851, DOI: 10.1002/anie.201807144
ZHANG HONG, WU XINXIN, WEI YUNLONG, ZHU CHEN: "Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 18, 20 September 2019 (2019-09-20), US , pages 7568 - 7572, XP093090095, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02838
NAEEM IQBAL; NAILA IQBAL; DEBABRATA MAITI; EUN JIN CHO: "Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of the Anti‐Arrhythmic Drug Amiodarone", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 58, no. 44, 20 September 2019 (2019-09-20), Hoboken, USA, pages 15808 - 15812, XP072091600, ISSN: 1433-7851, DOI: 10.1002/anie.201909015
LIU YUEJIN, RONG SHIHONG: "Study on the antitumor activity of hydroxycholanic acid derivatives Synthesis and in vitro antitumor activity of 3β,5α,6β-trihydroxycholanic acid derivatives and 3β,6β-dihydroxychol-4-enic acid derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 6, 2004, pages 344 - 349, XP009548614
XIAOXU QI; PINHONG CHEN; GUOSHENG LIU: "Catalytic Oxidative Trifluoromethoxylation of Allylic C−H Bonds Using a Palladium Catalyst", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 56, no. 32, 6 July 2017 (2017-07-06), Hoboken, USA, pages 9517 - 9521, XP072092992, ISSN: 1433-7851, DOI: 10.1002/anie.201703841
HAODONG YANG; FENG WANG; XIAOHUAN JIANG; YU ZHOU; XIUFANG XU; PINGPING TANG: "Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 57, no. 40, 4 September 2018 (2018-09-04), Hoboken, USA, pages 13266 - 13270, XP072096229, ISSN: 1433-7851, DOI: 10.1002/anie.201807144
ZHANG HONG, WU XINXIN, WEI YUNLONG, ZHU CHEN: "Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 18, 20 September 2019 (2019-09-20), US , pages 7568 - 7572, XP093090095, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02838
NAEEM IQBAL; NAILA IQBAL; DEBABRATA MAITI; EUN JIN CHO: "Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of the Anti‐Arrhythmic Drug Amiodarone", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 58, no. 44, 20 September 2019 (2019-09-20), Hoboken, USA, pages 15808 - 15812, XP072091600, ISSN: 1433-7851, DOI: 10.1002/anie.201909015
Attorney, Agent or Firm:
SIKS & CO. (JP)
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