Title:
COMPOUND AND METHOD FOR PRODUCING SAME, AS WELL AS METHOD FOR PRODUCING OSELTAMIVIR PHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2012/121079
Kind Code:
A1
Abstract:
Provided is a compound represented by general formula (1). Also provided is a method for producing a compound represented by formula (1) that comprises a reaction step for reacting a compound represented by general formula (2), a compound represented by general formula (3), and a compound represented by general formula (4). In general formulas (1) through (4), R1 is a protector group of a carboxyl group or a hydrogen atom; R2 and R3 are each independently a protector group of an amino group or a hydrogen atom; and R4 is a protector group of a carboxyl group or a hydrogen atom.
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Inventors:
SHIBASAKI MASAKATSU (JP)
YAMATSUGU KENZO (JP)
YAMATSUGU KENZO (JP)
Application Number:
PCT/JP2012/055085
Publication Date:
September 13, 2012
Filing Date:
February 29, 2012
Export Citation:
Assignee:
MICROBIAL CHEM RES FOUND (JP)
SHIBASAKI MASAKATSU (JP)
YAMATSUGU KENZO (JP)
SHIBASAKI MASAKATSU (JP)
YAMATSUGU KENZO (JP)
International Classes:
C07C229/30; A61K31/225; A61P31/12; C07C227/10; C07C227/16; C07C227/32; C07C229/48; C07C269/04; C07C269/06; C07C271/24; C07B53/00; C07B61/00
Other References:
LOUKAS,V. ET AL.: "Efficient protocols for the synthesis of enantiopure y-amino acids with proteinogenic side chains", JOURNAL OF PEPTIDE SCIENCE, vol. 9, no. 5, 2003, pages 312 - 319, XP055128143
MURRAY,W.V. ET AL.: "Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction", TETRAHEDRON LETTERS, vol. 43, no. 41, 2002, pages 7389 - 7392, XP004389300
DRAGOVICH,P.S. ET AL.: "Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 15, 1998, pages 2819 - 2834, XP002100727
KIPASSA,N.T. ET AL.: "Efficient short step synthesis of Corey's Tamiflu intermediate", ORGANIC LETTERS, vol. 10, no. 5, 2008, pages 815 - 816, XP055122649
BROMFIELD,K.M. ET AL.: "An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir", CHEMICAL COMMUNICATIONS, 2007, CAMBRIDGE, UNITED KINGDOM, pages 3183 - 3185, XP055122651
J. AM. CHEM. SOC., vol. 119, 1997, pages 681
J. AM. CHEM. SOC., vol. 128, 2006, pages 6310
ORG. LET., vol. 10, 2008, pages 815
GREEN ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
ANASTASI, C; HANTZ, 0.; CLERCQ, E. D.; PANNECOUQUE, C.; CLAYETTE, P.; DEREUDDRE-BOSQUET, N.; DORMONT, D.; GONDOIS-REY, F.; HIRSCH,, J. MED. CHEM., vol. 47, 2004, pages 1183
LEE, O.-Y.; LAW, K.-L.; YANG, D., ORG. LETT., vol. 11, 2009, pages 3302
MURRAY,W.V. ET AL.: "Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction", TETRAHEDRON LETTERS, vol. 43, no. 41, 2002, pages 7389 - 7392, XP004389300
DRAGOVICH,P.S. ET AL.: "Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 15, 1998, pages 2819 - 2834, XP002100727
KIPASSA,N.T. ET AL.: "Efficient short step synthesis of Corey's Tamiflu intermediate", ORGANIC LETTERS, vol. 10, no. 5, 2008, pages 815 - 816, XP055122649
BROMFIELD,K.M. ET AL.: "An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir", CHEMICAL COMMUNICATIONS, 2007, CAMBRIDGE, UNITED KINGDOM, pages 3183 - 3185, XP055122651
J. AM. CHEM. SOC., vol. 119, 1997, pages 681
J. AM. CHEM. SOC., vol. 128, 2006, pages 6310
ORG. LET., vol. 10, 2008, pages 815
GREEN ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
ANASTASI, C; HANTZ, 0.; CLERCQ, E. D.; PANNECOUQUE, C.; CLAYETTE, P.; DEREUDDRE-BOSQUET, N.; DORMONT, D.; GONDOIS-REY, F.; HIRSCH,, J. MED. CHEM., vol. 47, 2004, pages 1183
LEE, O.-Y.; LAW, K.-L.; YANG, D., ORG. LETT., vol. 11, 2009, pages 3302
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
Koichi Hirota (JP)
Koichi Hirota (JP)
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