COMPOUND OF N-(9,13B-DIHYDRO-1H-DIBENZO[C,F]IMIDAZO[1,5-A]AZEPINE-3-YL)-2-HYDROXYBENZAMIDE AND 2-((9,13B-DIHYDRO-1H-DIBENZO[C,F]IMIDAZO[1,5-A]AZEPINE-3-YL) CARBAMOYL)PHENYL ACETATE, PREPARATION METHOD THEREFOR, AND ANTI-INFLAMMATORY AND ANALGESIC AGENT CONTAINING SAME

WIPO Patent Application WO/2019/117592

A1

The present invention relates to a compound of N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine-3-yl)-2-hydroxybenzamide and 2-((9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine-3-yl) carbamoyl)phenyl acetate, a preparation method therefor, and a composition containing the same, and provides a compound having excellent anti-inflammatory and pain control effects, a preparation method therefor and a composition for preventing or treating inflammation and/or pain, containing the compound as an active ingredient.

SUH HONG WON (KR)
LEE JAE YONG (KR)
LIM SOON SUNG (KR)
LEE JEONG TAE (KR)
HWANG SEUNG HWAN (KR)
JANG SANG PIL (KR)
PARK SUNG HWAN (KR)
JEON JEONG HO (KR)
LIM HYUN MIN (KR)
LEE JU MI (KR)

PCT/KR2018/015699

June 20, 2019

December 11, 2018

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FRONTBIO CO LTD (KR)

C07D487/04; A61K9/00; A61K31/55

WO2012032509A2	2012-03-15
WO2009109501A2	2009-09-11

US3725429A	1973-04-03
US4313931A	1982-02-02
CN105153169A	2015-12-16

VU, C. B.: "Synthesis and characterization of fatty acid conjugates of niacin and salicylic acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 3, 2016, pages 1217 - 1231, XP055618909, DOI: 10.1021/acs.jmedchem.5b01961
EDWARD BARRY, BORER LONDA L: "Experiments with aspirin", JOURNAL OF CHEMICAL EDUCATION, vol. 77, no. 3, 2000, pages 354 - 355, XP055618912, DOI: 10.1021/ed077p354

LEE, Jeong-Hoon (KR)

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