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Title:
COMPOUND, NUCLEIC ACID, LABELING SUBSTANCE, AND DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2014/038561
Kind Code:
A1
Abstract:
Provided is a compound, a tautomer of said compound, a stereoisomer of said compound, or a salt of the compound, tautomer, or stereoisomer that is characterized by being represented by chemical formula (I). L is a single bond or a linker (crosslinking atom or group of atoms) and Z is either a group of atoms capable of forming a peptide bond with a labeling compound or an atom or group of atoms that contains a label.

Inventors:
HAYASHIZAKI Yoshihide (22-8, Inarimae Tsukuba-sh, Ibaraki 61, 〒3050061, JP)
SOMA Takahiro (205 Famille Grand Kawano, 2-15-18 Hiratsuka, Shinagawa-k, Tokyo 51, 〒1420051, JP)
HANAMI Takeshi (1-31-7, Higashiterao Tsurumi-ku, Yokohama-sh, Kanagawa 77, 〒2300077, JP)
KANAMORI Hajime (306 Residence Kasuga, 1-29-18 Kasuga, Ageo-sh, Saitama 74, 〒3620074, JP)
BABA Masaru (75-1 Ono-cho, Tsurumi-ku, Yokohama-sh, Kanagawa 46, 〒2300046, JP)
Application Number:
JP2013/073721
Publication Date:
March 13, 2014
Filing Date:
September 03, 2013
Export Citation:
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Assignee:
KABUSHIKI KAISHA DNAFORM (75-1, Ono-cho Tsurumi-ku, Yokohama-sh, Kanagawa 46, 〒2300046, JP)
International Classes:
C07H19/073; C07H21/04
Domestic Patent References:
WO2008111485A12008-09-18
WO2012091091A12012-07-05
WO2011132801A12011-10-27
Foreign References:
JP2006047183A2006-02-16
JP2008526877A2008-07-24
JP2002507203A2002-03-05
JP4370385B22009-11-25
JP3897805B22007-03-28
Other References:
IKEDA, SHUJI ET AL.: "Doubly thiazole orange- labeled cytidine for functional expansion of a hybridization-sensitive probe", TETRAHEDRON LETTERS, vol. 50, no. 51, 2009, pages 7191 - 7195, XP026738120
OKAMOTO, AKIMITSU: "Excitonic Interaction: Another Photophysical Process for Fluorescence- Controlled Nucleic Acid Sensin", THE CHEMICAL RECORD, vol. 10, 2010, pages 188 - 196, XP055113970
SHUJI IKEDA ET AL.: "Kakusan Kenshutsu no Tameno Shinki Keiko Probe", SYMPOSIUM ON PHOTOCHEMISTRY, 21 September 2007 (2007-09-21), pages 182, XP008178464
IKEDA, SHUJI ET AL.: "pH-Dependent fluorescence of uncharged benzothiazole-based dyes binding to DNA", PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, vol. 6, no. 11, 2007, pages 1197 - 1201, XP055113969
See also references of EP 2894158A4
H. S. RYE; M. A. QUESADA; K. PECK; R. A. MATHIES; A. N. GLAZER: "High-sensitivity two-color detection of double-stranded DNA with a confocal fluorescence gel scanner using ethidium homodimer and thiazole orange", NUCLEIC ACIDS RES., vol. 19, 1991, pages 327 - 33
L. G. LEE; C. H. CHEN; L. A. CHIU: "Thiazole orange: a new dye for reticulocyte analysis", CYTOMETRY, vol. 7, 1986, pages 508 - 17
TETRAHEDRON LETTERS, vol. 50, 2009, pages 7191
NATURE METHODS, vol. 4, no. 3, 2007, pages 257
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (301 Bldg. 1, Kyoto Research Park 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto-sh, Kyoto 13, 〒6008813, JP)
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