Title:
COMPOUND FOR REMOVING HUMAN PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2018/043567
Kind Code:
A1
Abstract:
The purpose of the present invention is to discover a cytotoxic anticancer drug that serves as a common substrate for both ABCB1 and ABCG2 which are suppressed in human pluripotent stem cells, and to provide a method for efficiently removing undifferentiated cells using said drug. Specifically, the present invention pertains to: a compound represented by formula (I); synthesis intermediates thereof; a method in which said compound is used to remove undifferentiated cells in a cell population in which the differentiation of stem cells has been induced; and a drug that selectively damages cells that express ABCB1 and ABCG2 transporters, the drug containing said compound as an active ingredient.
Inventors:
UESUGI MOTONARI (JP)
DI MAO (JP)
KAWASE EIHACHIRO (JP)
DI MAO (JP)
KAWASE EIHACHIRO (JP)
Application Number:
PCT/JP2017/031165
Publication Date:
March 08, 2018
Filing Date:
August 30, 2017
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07D311/80; C07D491/22; C12N5/0735; C12N5/074; C12N5/0789; C12N5/0797; C12N5/10
Domestic Patent References:
| WO2015063553A2 | 2015-05-07 | |||
| WO2012027266A2 | 2012-03-01 |
Foreign References:
| JP2015505240A | 2015-02-19 | |||
| JP2010126533A | 2010-06-10 | |||
| JP2001233883A | 2001-08-28 | |||
| JP2004138397A | 2004-05-13 | |||
| JP2005333904A | 2005-12-08 | |||
| US20090227467A1 | 2009-09-10 |
Other References:
DAVID, U. B. ET AL.: "Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen", CELL STEM CELL, vol. 12, February 2013 (2013-02-01), pages 167 - 179, XP055072276
HIDENORI, I. ET AL., BIO INDUSTRY, vol. 33, no. 2, 12 February 2016 (2016-02-12), pages 4 - 10
CHOO, A. B. ET AL.: "Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1", STEM CELLS, vol. 26, 2008, pages 1454 - 1463, XP002538481
SAMORI, C. ET AL.: "Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers", CHEMICAL COMMUNICATIONS, vol. 46, no. 9, 2010, pages 1494 - 1496, XP055604014
HIDENORI, I. ET AL., BIO INDUSTRY, vol. 33, no. 2, 12 February 2016 (2016-02-12), pages 4 - 10
CHOO, A. B. ET AL.: "Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1", STEM CELLS, vol. 26, 2008, pages 1454 - 1463, XP002538481
SAMORI, C. ET AL.: "Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers", CHEMICAL COMMUNICATIONS, vol. 46, no. 9, 2010, pages 1494 - 1496, XP055604014
Attorney, Agent or Firm:
NAKATANI Tomoko (JP)
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