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Title:
COMPOUND OF RESORCINOL DERIVATIVE WITH POLYMER
Document Type and Number:
WIPO Patent Application WO/2008/041610
Kind Code:
A1
Abstract:
A compound of a resorcinol derivative with a polymer. It is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug amount than the resorcinol derivative. The compound of a resorcinol derivative with a polymer comprises a polyethylene glycol structural part, a polymer part having carboxy groups in side chains, and a resorcinol derivative in which a hydroxy group has been bonded to a carboxy group of the polymer part through an ester linkage.

Inventors:
NAKAMURA, Masaharu (3-31-12 Shimo, Kita-k, Tokyo 88, 1158588, JP)
中村 雅陽 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
KITAGAWA, Masayuki (3-31-12 Shimo, Kita-k, Tokyo 88, 1158588, JP)
北川 正行 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
Application Number:
JP2007/068841
Publication Date:
April 10, 2008
Filing Date:
September 27, 2007
Export Citation:
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Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA (11-2, Fujimi 1-chome Chiyoda-k, Tokyo 72, 1028172, JP)
日本化薬株式会社 (〒72 東京都千代田区富士見一丁目11番2号 Tokyo, 1028172, JP)
NAKAMURA, Masaharu (3-31-12 Shimo, Kita-k, Tokyo 88, 1158588, JP)
中村 雅陽 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
KITAGAWA, Masayuki (3-31-12 Shimo, Kita-k, Tokyo 88, 1158588, JP)
International Classes:
C08G85/00; A61K31/787; A61P35/00; C08G81/00
Domestic Patent References:
WO2004039869A12004-05-13
WO2005000300A12005-01-06
WO2005018674A12005-03-03
WO2006055760A12006-05-26
WO2006095783A12006-09-14
WO2003055860A12003-07-10
WO2004050087A12004-06-17
WO2004056782A12004-07-08
WO2004096212A12004-11-11
WO2004072051A12004-08-26
WO2005000300A12005-01-06
WO2006055760A12006-05-26
WO2005018674A12005-03-03
WO2006095783A12006-09-14
WO2004039869A12004-05-13
Foreign References:
JPH05955A1993-01-08
JP2894923B21999-05-24
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JP3268913B22002-03-25
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Other References:
LEN NECKERS: "Hsn90 inhibitors as nobel cancer chemotherapeutic agents", TRENDS IN MOLECULAR MEDICINE, vol. 8, no. 4, SUPPL. 1, 2002, pages 55 - 61, XP002246588
See also references of EP 2070971A4
"Hsp90 inhibitors as novel cancer chemotherapeutic agents", TRENDS MOL MED., vol. 8, no. 4, 2002, pages 55 - 61
"The clinical applications of heat shock protein inhibitors in cancer - present and future", CURR. CANCER DRUG TARGETS., vol. 3, no. 5, October 2003 (2003-10-01), pages 385 - 390, XP009053559, DOI: doi:10.2174/1568009033481813
VILENCHIK, M. ET AL.: "Targeting wide-range oncogenic transformation via PU24FC1, A specific inhibitor of tumor Hsp90", CHEM. BIOL., vol. 11, 2004, pages 787 - 797, XP025940201, DOI: doi:10.1016/j.chembiol.2004.04.008
Attorney, Agent or Firm:
KAWAGUCHI, Yoshio et al. (Kawaguti & Partners, Jochi Kioizaka Bldg.7-1 Kioi-cho, Chiyoda-ku, Tokyo 94, 1020094, JP)
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