Title:
COMPOUND RETAINED IN TUMOR
Document Type and Number:
WIPO Patent Application WO/2010/082634
Kind Code:
A1
Abstract:
Provided are a novel compound which is retained specifically in a tumor, a method for retaining the compound in a tumor, and a method for detecting, diagnosing and treating a tumor using the same. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
In formula (I), R represents an anionic group bonded to hydrogen; R1 represents OH, OCOH, OCO(CH2)hCH3 or a functional group wherein h represents an integer greater than or equal to 0; R2 represents H, OH, OCOH, OCO(CH2)iCH3 or a functional group wherein i represents an integer greater than or equal to 0; R3 represents OH, SO3H or a functional group; R4 represents OH, SO3H or a functional group; and R5 represents OH, SO3H or a functional group, provided that at least one of R1, R2, R3, R4 and R5 comprises a functional group.
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Inventors:
OHTA KEISUKE (JP)
MIURA MASAHIKO (JP)
SAKAGUCHI KENGO (JP)
SUGAWARA FUMIO (JP)
ISHIMA MASAHIRO (JP)
MURATA HIROSHI (JP)
MIURA MASAHIKO (JP)
SAKAGUCHI KENGO (JP)
SUGAWARA FUMIO (JP)
ISHIMA MASAHIRO (JP)
MURATA HIROSHI (JP)
Application Number:
PCT/JP2010/050432
Publication Date:
July 22, 2010
Filing Date:
January 15, 2010
Export Citation:
Assignee:
TOYO SUISAN KAISHA (JP)
OHTA KEISUKE (JP)
MIURA MASAHIKO (JP)
SAKAGUCHI KENGO (JP)
SUGAWARA FUMIO (JP)
ISHIMA MASAHIRO (JP)
MURATA HIROSHI (JP)
OHTA KEISUKE (JP)
MIURA MASAHIKO (JP)
SAKAGUCHI KENGO (JP)
SUGAWARA FUMIO (JP)
ISHIMA MASAHIRO (JP)
MURATA HIROSHI (JP)
International Classes:
C07H15/26; A61K47/48; A61K49/00; A61K49/04; A61K51/00
Other References:
YAMAZAKI, T. ET AL.: "Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 16, 2004, pages 4343 - 4346, XP055098406
AOKI, S. ET AL.: "Mammalian mitotic centromere- associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents", FEBS J, vol. 272, no. 9, 2005, pages 2132 - 2140, XP055098404
HANASHIMA, S. ET AL.: "Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols", JPN J CANCER RES, vol. 91, no. 10, 2000, pages 1073 - 1083, XP002945479
HANASHIMA, S. ET AL.: "Structural determination of sulfoquinovosyldiacylglycerol by chiral syntheses", TETRAHEDRON LETT, vol. 41, 2000, pages 4403 - 4407, XP004205578
HANASHIMA, S. ET AL.: "Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta", BIOORG MED CHEM, vol. 9, no. 2, 2001, pages 367 - 376, XP055098403
SAHARA, H. ET AL.: "In vivo anti-tumour effect of 3'-sulphonoquinovosyl I'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine", BR J CANCER, vol. 75, no. 3, 1997, pages 324 - 332, XP002928277
AOKI, S. ET AL.: "Mammalian mitotic centromere- associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents", FEBS J, vol. 272, no. 9, 2005, pages 2132 - 2140, XP055098404
HANASHIMA, S. ET AL.: "Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols", JPN J CANCER RES, vol. 91, no. 10, 2000, pages 1073 - 1083, XP002945479
HANASHIMA, S. ET AL.: "Structural determination of sulfoquinovosyldiacylglycerol by chiral syntheses", TETRAHEDRON LETT, vol. 41, 2000, pages 4403 - 4407, XP004205578
HANASHIMA, S. ET AL.: "Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta", BIOORG MED CHEM, vol. 9, no. 2, 2001, pages 367 - 376, XP055098403
SAHARA, H. ET AL.: "In vivo anti-tumour effect of 3'-sulphonoquinovosyl I'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine", BR J CANCER, vol. 75, no. 3, 1997, pages 324 - 332, XP002928277
Attorney, Agent or Firm:
SUZUYE, Takehiko et al. (JP)
Takehiko Suzue (JP)
Takehiko Suzue (JP)
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