Title:
COMPOUND, SALT THEREOF AND LIPID PARTICLES
Document Type and Number:
WIPO Patent Application WO/2019/235635
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid particles which use this compound or a salt thereof, and which enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery. The present invention provides a compound represented by formula (1) or a salt thereof. In the formula, X represents -NR1- or -O-; R1 represents a hydrogen atom, a hydrocarbon group or the like; each of R2 and R3 independently represents a hydrogen atom, a hydrocarbon group or the like; each of R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently represents a hydrogen atom, an alkyl group or the like; one or more pairs selected from among a pair of R4 and R5, a pair of R10 and R5, a pair of R5 and R12, a pair of R4 and R6, a pair of R5 and R6, a pair of R6 and R7, a pair of R6 and R10, a pair of R12 and R7, and a pair of R7 and R8 may combine with each other and form a 4- to 7-membered ring that may contain an O atom; and each of a, b, c and d independently represents an integer of 0-3, provided that (a + b) is 1 or more and (c + d) is 1 or more.
Inventors:
TANABE SHINTARO (JP)
YAMAMOTO MASAHIKO (JP)
SATO KIMIHIKO (JP)
TAKAHASHI MOTOMASA (JP)
TSUNA KAZUHIRO (JP)
TASAKI YASUTAKA (JP)
ENDO TAISUKE (JP)
DOI ISSEI (JP)
FUKUNAGA HIROFUMI (JP)
YAMAMOTO MASAHIKO (JP)
SATO KIMIHIKO (JP)
TAKAHASHI MOTOMASA (JP)
TSUNA KAZUHIRO (JP)
TASAKI YASUTAKA (JP)
ENDO TAISUKE (JP)
DOI ISSEI (JP)
FUKUNAGA HIROFUMI (JP)
Application Number:
PCT/JP2019/022833
Publication Date:
December 12, 2019
Filing Date:
June 07, 2019
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07C219/16; A61K9/127; A61K9/14; A61K9/51; A61K31/7088; A61K47/10; A61K47/14; A61K47/18; A61K47/22; A61K47/24; A61K47/28; C07C271/12; C07C271/16; C07C271/22; C07D211/42; C07D211/46; C07D295/13
Domestic Patent References:
WO2014007398A1 | 2014-01-09 | |||
WO2015005253A1 | 2015-01-15 | |||
WO2010054401A1 | 2010-05-14 | |||
WO2010144740A1 | 2010-12-16 | |||
WO2010054405A1 | 2010-05-14 | |||
WO2014007398A1 | 2014-01-09 | |||
WO2015005253A1 | 2015-01-15 | |||
WO2013059496A1 | 2013-04-25 | |||
WO2016081029A1 | 2016-05-26 | |||
WO2010054401A1 | 2010-05-14 | |||
WO2015005253A1 | 2015-01-15 | |||
WO2014007398A1 | 2014-01-09 |
Foreign References:
JPH06298712A | 1994-10-25 | |||
JP2015501309A | 2015-01-15 | |||
US20160317458A1 | 2016-11-03 | |||
JP5288254B2 | 2013-09-11 |
Other References:
DATABASE Registry [online] American Chemical Society; 29 September 2016 (2016-09-29), retrieved from STN Database accession no. RN 2001907- 05-5
DATABASE Registry [online] American Chemical Society; 28 September 2016 (2016-09-28), retrieved from STN Database accession no. RN 2001651-45-0
DATABASE Registry [online] American Chemical Society; 29 September 2016 (2016-09-29), retrieved from STN Database accession no. RN 2001788-05-0
DATABASE Registry [online] American Chemical Society; 2 October 2016 (2016-10-02), retrieved from STN Database accession no. RN 2003930-61-6
DATABASE Registry [online] American Chemical Society; 16 October 2016 (2016-10-16), retrieved from STN Database accession no. RN 2012853- 22-2
DATABASE Registry [online] American Chemical Society; 5 October 2016 (2016-10-05), retrieved from STN Database accession no. RN 2005720-56-7
DATABASE Registry [online] American Chemical Society; 3 November 2016 (2016-11-03), retrieved from STN Database accession no. RN 2024626-33-1
DATABASE Registry [online] American Chemical Society; 13 November 2016 (2016-11-13), retrieved from STN Database accession no. RN 2030447- 26-6
DATABASE Registry [online] American Chemical Society; 4 January 2018 (2018-01-04), retrieved from STN Database accession no. RN 2169605-81-4
DATABASE Registry [online] American Chemical Society; 21 October 2016 (2016-10-21), retrieved from STN Database accession no. 2016779-95-4
DATABASE Registry [online] American Chemical Society; 10 December 2017 (2017-12-10), retrieved from STN Database accession no. 2155113-73-6
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, 2016, pages l34 - 145
NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 172 - 176
See also references of EP 3805198A4
DATABASE Registry [online] American Chemical Society; 28 September 2016 (2016-09-28), retrieved from STN Database accession no. RN 2001651-45-0
DATABASE Registry [online] American Chemical Society; 29 September 2016 (2016-09-29), retrieved from STN Database accession no. RN 2001788-05-0
DATABASE Registry [online] American Chemical Society; 2 October 2016 (2016-10-02), retrieved from STN Database accession no. RN 2003930-61-6
DATABASE Registry [online] American Chemical Society; 16 October 2016 (2016-10-16), retrieved from STN Database accession no. RN 2012853- 22-2
DATABASE Registry [online] American Chemical Society; 5 October 2016 (2016-10-05), retrieved from STN Database accession no. RN 2005720-56-7
DATABASE Registry [online] American Chemical Society; 3 November 2016 (2016-11-03), retrieved from STN Database accession no. RN 2024626-33-1
DATABASE Registry [online] American Chemical Society; 13 November 2016 (2016-11-13), retrieved from STN Database accession no. RN 2030447- 26-6
DATABASE Registry [online] American Chemical Society; 4 January 2018 (2018-01-04), retrieved from STN Database accession no. RN 2169605-81-4
DATABASE Registry [online] American Chemical Society; 21 October 2016 (2016-10-21), retrieved from STN Database accession no. 2016779-95-4
DATABASE Registry [online] American Chemical Society; 10 December 2017 (2017-12-10), retrieved from STN Database accession no. 2155113-73-6
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, 2016, pages l34 - 145
NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 172 - 176
See also references of EP 3805198A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
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