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Title:
COMPOUND, SALT THEREOF AND LIPID PARTICLES
Document Type and Number:
WIPO Patent Application WO/2019/235635
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid particles which use this compound or a salt thereof, and which enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery. The present invention provides a compound represented by formula (1) or a salt thereof. In the formula, X represents -NR1- or -O-; R1 represents a hydrogen atom, a hydrocarbon group or the like; each of R2 and R3 independently represents a hydrogen atom, a hydrocarbon group or the like; each of R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently represents a hydrogen atom, an alkyl group or the like; one or more pairs selected from among a pair of R4 and R5, a pair of R10 and R5, a pair of R5 and R12, a pair of R4 and R6, a pair of R5 and R6, a pair of R6 and R7, a pair of R6 and R10, a pair of R12 and R7, and a pair of R7 and R8 may combine with each other and form a 4- to 7-membered ring that may contain an O atom; and each of a, b, c and d independently represents an integer of 0-3, provided that (a + b) is 1 or more and (c + d) is 1 or more.

Inventors:
TANABE SHINTARO (JP)
YAMAMOTO MASAHIKO (JP)
SATO KIMIHIKO (JP)
TAKAHASHI MOTOMASA (JP)
TSUNA KAZUHIRO (JP)
TASAKI YASUTAKA (JP)
ENDO TAISUKE (JP)
DOI ISSEI (JP)
FUKUNAGA HIROFUMI (JP)
Application Number:
PCT/JP2019/022833
Publication Date:
December 12, 2019
Filing Date:
June 07, 2019
Export Citation:
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Assignee:
FUJIFILM CORP (JP)
International Classes:
C07C219/16; A61K9/127; A61K9/14; A61K9/51; A61K31/7088; A61K47/10; A61K47/14; A61K47/18; A61K47/22; A61K47/24; A61K47/28; C07C271/12; C07C271/16; C07C271/22; C07D211/42; C07D211/46; C07D295/13
Domestic Patent References:
WO2014007398A12014-01-09
WO2015005253A12015-01-15
WO2010054401A12010-05-14
WO2010144740A12010-12-16
WO2010054405A12010-05-14
WO2014007398A12014-01-09
WO2015005253A12015-01-15
WO2013059496A12013-04-25
WO2016081029A12016-05-26
WO2010054401A12010-05-14
WO2015005253A12015-01-15
WO2014007398A12014-01-09
Foreign References:
JPH06298712A1994-10-25
JP2015501309A2015-01-15
US20160317458A12016-11-03
JP5288254B22013-09-11
Other References:
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T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
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See also references of EP 3805198A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
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