Title:
COMPOUND SUITABLE FOR DETECTING AGGREGATED PROTEIN
Document Type and Number:
WIPO Patent Application WO/2019/026797
Kind Code:
A1
Abstract:
A compound represented by formula (I) has a high selective capability to bind to aggregated proteins. (In the formula, R1 represents a C1-6 alkyl group, a C1-6 alkyl group substituted by a halogen atom, or –11CH3; R2 represents -CH3 or –11CH3, but R1 and R2 do not simultaneously represent –11CH3; one of Ra, Rb, Rc, and Rd is a halogen atom, and the remaining three are hydrogen atoms.)
Inventors:
NARUMI TETSUO (JP)
IMAI TOMOYUKI (JP)
MASE NOBUYUKI (JP)
SATO KOHEI (JP)
IMAI TOMOYUKI (JP)
MASE NOBUYUKI (JP)
SATO KOHEI (JP)
Application Number:
PCT/JP2018/028279
Publication Date:
February 07, 2019
Filing Date:
July 27, 2018
Export Citation:
Assignee:
UNIV SHIZUOKA NAT UNIV CORP (JP)
International Classes:
C07D417/06; A61K49/00; G01T1/161
Domestic Patent References:
| WO2014097474A1 | 2014-06-26 |
Foreign References:
| JPS3919653B1 |
Other References:
MARUYAMA, MASANIRO ET AL.: "imaging or Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls", NEURON, vol. 79, no. 6, 2013, pages 1094 - 1108, XP028720119, ISSN: 0896-6273
HASHIMOTO, HIROKI ET AL.: "Radiosynthesis, photoisomerization, biodistribution, and metabolite analysis of 11C-PBB3 as a clinically useful PET probe for imaging of tau pathology", JOURNAL OF NUCLEAR MEDICINE, vol. 55, no. 9, 2014, pages 1532 - 1538, XP055572719, ISSN: 0161-5505
IMAI, TOMOYUKI ET AL.: "Synthesis of chloroalkane skeleton-containing PBB3 derivatives aiming at tau imaging, and evaluation of light stability", 137TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2017 (2017-03-05), pages 106, Retrieved from the Internet [retrieved on 20170201]
IMAI, TOMOYUKI ET AL.: "Research on formation of novel tau protein-imaging agent having high light-stability", LECTURE ABSTRACTS OF THE 2017 COLLABORATIVE ACADEMIC CONFERENCE OF TOKAI BLOCKS OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS AND TOKAI BRANCHES OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS, 26 November 2017 (2017-11-26), pages 151
HASHIMOTO, HIROKI ET AL.: "Radiosynthesis, photoisomerization, biodistribution, and metabolite analysis of 11C-PBB3 as a clinically useful PET probe for imaging of tau pathology", JOURNAL OF NUCLEAR MEDICINE, vol. 55, no. 9, 2014, pages 1532 - 1538, XP055572719, ISSN: 0161-5505
IMAI, TOMOYUKI ET AL.: "Synthesis of chloroalkane skeleton-containing PBB3 derivatives aiming at tau imaging, and evaluation of light stability", 137TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2017 (2017-03-05), pages 106, Retrieved from the Internet
IMAI, TOMOYUKI ET AL.: "Research on formation of novel tau protein-imaging agent having high light-stability", LECTURE ABSTRACTS OF THE 2017 COLLABORATIVE ACADEMIC CONFERENCE OF TOKAI BLOCKS OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS AND TOKAI BRANCHES OF JAPANESE SOCIETY OF HOSPITAL PHARMACISTS, 26 November 2017 (2017-11-26), pages 151
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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