Title:
COMPOUND THAT INHIBITS PROGRAMMED CELL NECROSIS, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/040818
Kind Code:
A1
Abstract:
Disclosed are a RIPK1 inhibitor that inhibits programmed cell necrosis and a preparation method therefor. The disclosed RIK1 inhibitor is represented by general formula I, where X1, X2, X3, X4, X5, Z1, Z2, Z3, L1, L2, L3, R, R1, ring D and n are shown in the description and claims. Further disclosed are a method for preparing general formula I and an activity test result of inhibition of programmed cell necrosis and RIPK1. The compound of general formula I of the present invention can be used to prepare drugs for treating and preventing inflammation and degenerative diseases.
Inventors:
WANG ZHAOYIN (CN)
YANG SHUAILONG (CN)
ZHAO ZHIMIN (CN)
YANG SHUAILONG (CN)
ZHAO ZHIMIN (CN)
Application Number:
PCT/CN2022/118387
Publication Date:
March 23, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C07D487/06; A61K31/55; A61K31/551; A61K31/5517; A61P1/00; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/04; A61P31/14; A61P35/00; A61P37/06; A61P43/00; C07D413/12; C07D471/16; C07D519/00
Domestic Patent References:
| WO2019204537A1 | 2019-10-24 | |||
| WO2020001420A1 | 2020-01-02 |
Foreign References:
| CN112079839A | 2020-12-15 | |||
| CN110642874A | 2020-01-03 | |||
| CN111138448A | 2020-05-12 | |||
| CN109071558A | 2018-12-21 | |||
| CN105121432A | 2015-12-02 | |||
| US5607915A | 1997-03-04 |
Attorney, Agent or Firm:
SHANGHAI ZHI XIN PATENT AGENT LTD. (CN)
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