Title:
COMPOUND FOR TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/147971
Kind Code:
A1
Abstract:
Provided in the present invention are a compound as shown in formula I, various crystal forms thereof, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition. The compound of the present invention can effectively treat Alzheimer's disease or Down's syndrome, especially cognitive function impairment caused by Alzheimer's disease or Down's syndrome. Also disclosed in the present invention is use of a ubiquitin specific protease USP25 encoded and expressed by chromosome 21 for preventing, treating or ameliorating Alzheimer's disease or Down's syndrome.
Inventors:
WANG XIN (CN)
MA LEI (CN)
FU JIANJUN (CN)
ZHENG QIUYANG (CN)
ZHOU LICHENG (CN)
DENG QINGFANG (CN)
SHI XIMENG (CN)
LI GUILIN (CN)
WANG SHIHUA (CN)
DI ANJIE (CN)
MA LEI (CN)
FU JIANJUN (CN)
ZHENG QIUYANG (CN)
ZHOU LICHENG (CN)
DENG QINGFANG (CN)
SHI XIMENG (CN)
LI GUILIN (CN)
WANG SHIHUA (CN)
DI ANJIE (CN)
Application Number:
PCT/CN2021/073164
Publication Date:
July 29, 2021
Filing Date:
January 21, 2021
Export Citation:
Assignee:
UNIV XIAMEN (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
C07C217/58; A61K38/17; A61P25/28
Domestic Patent References:
| WO2016108045A2 | 2016-07-07 |
Foreign References:
| CN105408325A | 2016-03-16 | |||
| JP2016135778A | 2016-07-28 | |||
| CN109071561A | 2018-12-21 | |||
| CN109206503A | 2019-01-15 | |||
| CN109646668A | 2019-04-19 |
Other References:
WRIGLEY JONATHAN D., GAVORY GERALD, SIMPSON IAIN, PRESTON MARIAN, PLANT HELEN, BRADLEY JENNA, GOEPPERT ANNE U., ROZYCKA EWELINA, D: "Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily", ACS CHEMICAL BIOLOGY, vol. 12, no. 12, 15 December 2017 (2017-12-15), pages 3113 - 3125, XP055831187, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00334
WRIGLEY JONATHAN D., GAVORY GERALD, SIMPSON IAIN, PRESTON MARIAN, PLANT HELEN, BRADLEY JENNA, GOEPPERT ANNE U., ROZYCKA EWELINA, D: "Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily", ACS CHEMICAL BIOLOGY, vol. 12, no. 12, 15 December 2017 (2017-12-15), pages 3113 - 3125, XP055831187, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00334
LI GUILIN: "The Role of Ubiquitin-specific Protease USP25 in the Occurrence and Development of Alzheimer's Disease", CHINESE MASTER’S THESES FULL-TEXT DATABASE, 1 May 2018 (2018-05-01), XP055831309
WRIGLEY JONATHAN D., GAVORY GERALD, SIMPSON IAIN, PRESTON MARIAN, PLANT HELEN, BRADLEY JENNA, GOEPPERT ANNE U., ROZYCKA EWELINA, D: "Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily", ACS CHEMICAL BIOLOGY, vol. 12, no. 12, 15 December 2017 (2017-12-15), pages 3113 - 3125, XP055831187, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00334
LI GUILIN: "The Role of Ubiquitin-specific Protease USP25 in the Occurrence and Development of Alzheimer's Disease", CHINESE MASTER’S THESES FULL-TEXT DATABASE, 1 May 2018 (2018-05-01), XP055831309
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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