Title:
COMPOUND AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2019/141009
Kind Code:
A1
Abstract:
Disclosed are a compound and a pharmaceutically acceptable salt thereof, which can be used, by means of a chemical small molecule which targets both UHRF1 and HDAC1, or a pharmaceutically acceptable salt thereof, as corresponding inhibitors or drugs for treating diseases, and are used for treating myelodysplastic syndrome, psoriasis, scar hyperplasia, prostate or breast hyperplasia, hematologic neoplasms and solid cancers alone or combined with other methods. Same have a good therapeutic effect.
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Inventors:
LI XIONG (CN)
XIE GUOJIAN (CN)
XIE GUOJIAN (CN)
Application Number:
PCT/CN2018/119300
Publication Date:
July 25, 2019
Filing Date:
December 05, 2018
Export Citation:
Assignee:
CHANGSHA HOOZ BIOSCIENCE AND TECH CO LTD (CN)
International Classes:
C07D239/545; A61P13/08; A61P17/06; A61P35/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Domestic Patent References:
| WO2007095584A2 | 2007-08-23 |
Foreign References:
| CN103159646A | 2013-06-19 | |||
| CN107011270A | 2017-08-04 | |||
| CN106883217A | 2017-06-23 |
Other References:
YI-MIN LIU ET AL.: "Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells", ORGANIC&BIOMOLECULAR CHEMISTRY, 17 August 2015 (2015-08-17), XP055628073
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 114, 2016, pages 390 - 396
See also references of EP 3741748A4
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 114, 2016, pages 390 - 396
See also references of EP 3741748A4
Attorney, Agent or Firm:
CHANGSHA ZONEKEY PATENT LAW FIRM (CN)
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