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Title:
COMPOUND AND USE THEREOF IN PREPARING DRUG
Document Type and Number:
WIPO Patent Application WO/2017/101791
Kind Code:
A1
Abstract:
Disclosed are a compound and a use thereof in preparing a drug, and in particular, provided in the present invention are: the compound as shown in formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitroxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as shown in formula (I). Also disclosed is the use of the compound in the present invention in preparing a drug for treating cancer.

Inventors:
HE, Wei (Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
Application Number:
CN2016/109961
Publication Date:
June 22, 2017
Filing Date:
December 14, 2016
Export Citation:
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Assignee:
TSINGHUA UNIVERSITY (Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
International Classes:
C07C235/60; A61P35/00; C07C49/747; C07C225/22; C07C233/33; C07C237/30; C07C237/44; C07C255/57; C07D217/24; C07D231/56; C07D295/15
Domestic Patent References:
WO2014202779A12014-12-24
Foreign References:
CN105523955A2016-04-27
CN103351309A2013-10-16
CN1829437A2006-09-06
SE130522C1
DE4320801A11995-01-05
CN102531949A2012-07-04
Other References:
CLARK, C.R. ET AL.: "Liquid Chromatographic Studies on the Aqueous Solution Conformation of Substituted Benzamide Drug Models", JOURNAL OF CHROMATOGRAPHIC SCIENCE, vol. 27, no. 3, 31 December 1989 (1989-12-31), pages 111 - 117
WAGNER, G. ET AL.: "Preparation of Substituted Salicylguanidines", PHARMAZIE, vol. 29, no. 5, 31 December 1974 (1974-12-31), pages 352 - 353
MOHAMED, A.A. ET AL.: "Synthesis and Anti-Inflammatory Testing of Some New Compounds Incorporating 5-Aminosalicylic Acid (5-ASA) as Potential Prodrugs", ARCHIVES OF PHARMACAL RESEARCH, vol. 28, no. 6, 31 December 2005 (2005-12-31), pages 637 - 647
CIAMPA, G. ET AL.: "N-Substituted Salicylamides. II. Halogenated N-naphthyl-2-hydroxy-and N-naphthyl-2-acetoxybenzamides with Antibacterial and Antifungal Activity", RENDICONTO DELL' ACCADEMIA DELLE SCIENZE FISICHE E MATEMATICHE, vol. 33, 31 December 1966 (1966-12-31), NAPLES, pages 396 - 403
KISHORE, P.V.V.N. ET AL.: "Twelve-Membered B2Si406 Borasiloxane Macrocycles", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 743, 31 December 2013 (2013-12-31), pages 83 - 86, XP055391776
KRISHNAPRIYA, A.S. ET AL.: "RAS GTPase as the Drug Target for Anti-Cancer Designing of Drug from Template", KRISHNAPRIYA AND NAMBOORI , IJPSR, vol. 4, no. 11, 31 December 2013 (2013-12-31), pages 4457 - 4461, XP055391778
SUTO, M.J. ET AL.: "Dihydroisoquinolinones: the Design and Synthesis of a New Series of Potent Inhibitors of Poly (ADP-Ribose) Polymerase", ANTI-CANCER DRUG DESIGN, vol. 7, 31 December 2005 (2005-12-31), pages 107 - 117, XP002086825
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (Room 301 Trade Building, Zhaolanyuan Tsinghua University, Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
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