Title:
COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133151
Kind Code:
A1
Abstract:
The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.
Inventors:
LI YINGFU (CN)
HUANG HAOXI (CN)
LIU GUANFENG (CN)
CHEN TONGHUI (CN)
REN JUNFENG (CN)
SU ZHONGHAI (CN)
HUANG HAOXI (CN)
LIU GUANFENG (CN)
CHEN TONGHUI (CN)
REN JUNFENG (CN)
SU ZHONGHAI (CN)
Application Number:
PCT/CN2017/074108
Publication Date:
July 26, 2018
Filing Date:
February 20, 2017
Export Citation:
Assignee:
CHENGDU BRILLIANT PHARMACEUTICAL CO LTD (CN)
CHENGDU HIGHBRED PHARMACEUTICAL CO LTD (CN)
CHENGDU HIGHBRED PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4985; C07D487/04; A61K31/5383; A61P1/18; A61P11/00; A61P11/02; A61P11/06; A61P19/00; A61P19/02; A61P19/06; A61P29/00; C07D519/00
Domestic Patent References:
| WO2015132799A2 | 2015-09-11 | |||
| WO2013113097A1 | 2013-08-08 | |||
| WO2014140081A1 | 2014-09-18 | |||
| WO2011035332A1 | 2011-03-24 |
Foreign References:
| CN201710044771A | 2017-01-20 |
Other References:
TETRAHEDRON LETTERS, vol. 57, 2016, pages 599 - 602
JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 2, 1994, pages 276 - 277
See also references of EP 3572414A4
JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 2, 1994, pages 276 - 277
See also references of EP 3572414A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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