Title:
COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/164793
Kind Code:
A1
Abstract:
The present invention relates to a compound used as a kinase inhibitor and to the use thereof. The structure of the compound is as shown in formula I. The present compound used as a kinase inhibitor has good inhibitory activity on EGFR and Her2 exon 20 insertion mutations, and has excellent potential to be developed into a drug for treating related diseases.
Inventors:
LI JUN (CN)
LIANG APENG (CN)
NIU CHENGSHAN (CN)
WU YUSHENG (CN)
LIANG APENG (CN)
NIU CHENGSHAN (CN)
WU YUSHENG (CN)
Application Number:
PCT/CN2021/087725
Publication Date:
August 26, 2021
Filing Date:
April 16, 2021
Export Citation:
Assignee:
TYK MEDICINES ZHENGZHOU INC (CN)
International Classes:
C07D403/06; A61K31/517; A61P35/00; C07D401/12; C07D403/12; C07D405/14
Domestic Patent References:
| WO2015154725A1 | 2015-10-15 | |||
| WO2019120213A1 | 2019-06-27 | |||
| WO2008002039A1 | 2008-01-03 | |||
| WO2018084321A1 | 2018-05-11 |
Foreign References:
| CN112079830A | 2020-12-15 | |||
| CN104513229A | 2015-04-15 | |||
| CN108640928A | 2018-10-12 | |||
| CN103570692A | 2014-02-12 | |||
| CN101939316A | 2011-01-05 | |||
| CN107513040A | 2017-12-26 |
Other References:
ZHANG XU; PENG TING; JI XUN; LI JIAN; TONG LINJIANG; LI ZENG; YANG WEI; XU YUNGEN; LI MENGYUAN; DING JIAN; JIANG HUALIANG; XIE HUA: "Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 24, 2 October 2013 (2013-10-02), AMSTERDAM, NL, pages 7988 - 7998, XP028796463, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.09.049
MI YOUNG CHA, KWANG-OK LEE, JONG WOO KIM, CHANG GON LEE, JI YEON SONG, YOUNG HOON KIM, GWAN SUN LEE, SEUNG BUM PARK, MAENG SUP KIM: "Discovery of A Novel Her-1/Her-2 Dual Tyrosine Kinase Inhibitor for the Treatment of Her-1 Selective Inhibitor-Resistant Non-small Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 52, no. 21, 12 November 2009 (2009-11-12), pages 6880 - 6888, XP055220605, ISSN: 0022-2623, DOI: 10.1021/jm901146p
MI YOUNG CHA, KWANG-OK LEE, JONG WOO KIM, CHANG GON LEE, JI YEON SONG, YOUNG HOON KIM, GWAN SUN LEE, SEUNG BUM PARK, MAENG SUP KIM: "Discovery of A Novel Her-1/Her-2 Dual Tyrosine Kinase Inhibitor for the Treatment of Her-1 Selective Inhibitor-Resistant Non-small Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 52, no. 21, 12 November 2009 (2009-11-12), pages 6880 - 6888, XP055220605, ISSN: 0022-2623, DOI: 10.1021/jm901146p
Attorney, Agent or Firm:
ZHENGZHOU RUIXIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: