Title:
COMPOUND WHICH INHIBITS TELOMERE-BINDING PROTEIN, AND TELOMERE-BINDING PROTEIN INHIBITOR CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2019/181714
Kind Code:
A1
Abstract:
A compound according to the present invention is characterized by being represented by formula wherein: R1 represents an oxygen atom or a sulfur atom; and each of R2-R6 independently represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, an acyl group having 1-6 carbon atoms, or a nitro group.
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Inventors:
TAHARA HIDETOSHI (JP)
SHIROMA YOSHITOMO (JP)
TAKEDA KEI (JP)
SASAKI MICHIKO (JP)
SHIROMA YOSHITOMO (JP)
TAKEDA KEI (JP)
SASAKI MICHIKO (JP)
Application Number:
PCT/JP2019/010480
Publication Date:
September 26, 2019
Filing Date:
March 14, 2019
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
International Classes:
C07C323/37; A61K31/136; A61P35/00; C07C217/92; C07C225/22; C07K14/47
Domestic Patent References:
| WO2001030771A1 | 2001-05-03 | |||
| WO2009093667A1 | 2009-07-30 | |||
| WO2002044120A1 | 2002-06-06 |
Foreign References:
| JP2012507504A | 2012-03-29 | |||
| JP2001072592A | 2001-03-21 | |||
| JP2004524349A | 2004-08-12 | |||
| JPH07238066A | 1995-09-12 |
Other References:
DATABASE REGISTRY [online] 2001, XP55637640, Database accession no. 352638-37-0
SHIROMA, YOSHITOMO: "Effects of telomere binding protein TRF2 binding inhibitor on cancer cells", ABSTRACTS OF THE 76TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION, J-3119, 2017
SHIROMA, YOSHITOMO: "Development and functional analysis of telomere binding protein inhibitors using DSEFRET assay", ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, 2P-1435, 2017
SHIROMA YOSHITOMO: "TRF2- telomere DNA binding inhibitor obtained by applying DSE-FREAT assay", JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, w7-5, 2017
SHIROMA, YOSHITOMO: "Telomere binding protein TRF2 inhibitor obtained using DSE-FRET method", ABSTRACTS OF THE 20TH ANNUAL MEETING OF JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, P24-2, 2016
SHIROMA, YOSHITOMO: "Search for telomere binding protein TRF2 inhibitor using DSE-FRET method", ABSTRACTS OF THE 19TH ANNUAL MEETING OF JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, P3-3, 2015
GOMEZ, D. ET AL.: "Interaction of Telomestatin with the Telomeric Single-strand Overhang", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 40, 2004, pages 41487 - 41494, XP55637634
SHIROMA, YOSHITOMO: "Effects of telomere binding protein TRF2 binding inhibitor on cancer cells", ABSTRACTS OF THE 76TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION, J-3119, 2017
SHIROMA, YOSHITOMO: "Development and functional analysis of telomere binding protein inhibitors using DSEFRET assay", ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, 2P-1435, 2017
SHIROMA YOSHITOMO: "TRF2- telomere DNA binding inhibitor obtained by applying DSE-FREAT assay", JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, w7-5, 2017
SHIROMA, YOSHITOMO: "Telomere binding protein TRF2 inhibitor obtained using DSE-FRET method", ABSTRACTS OF THE 20TH ANNUAL MEETING OF JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, P24-2, 2016
SHIROMA, YOSHITOMO: "Search for telomere binding protein TRF2 inhibitor using DSE-FRET method", ABSTRACTS OF THE 19TH ANNUAL MEETING OF JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER PROGRAM, P3-3, 2015
GOMEZ, D. ET AL.: "Interaction of Telomestatin with the Telomeric Single-strand Overhang", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 40, 2004, pages 41487 - 41494, XP55637634
Attorney, Agent or Firm:
ISEKI Katsumori et al. (JP)
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