Title:
COMPOUND WITH BENZYLOXY AROMATIC RING STRUCTURE, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/244518
Kind Code:
A1
Abstract:
The present invention provides a compound with benzyloxy aromatic ring structure represented by general formula (I), a stereoisomer, enantiomer or pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing the same and a use thereof. The compound represented by the general formula (I) can be used to prepare small molecule inhibitors of PD1/PD-L1 interaction, which can be used to prevent and/or treat diseases related to PD1/PD-L1 interaction, particularly cancers, for example, particularly non-small cell lung cancer, small cell lung cancer, melanoma, head and neck cancer, kidney cancer, bladder cancer, locally advanced or metastatic urothelial cancer, breast cancer, cervical cancer, metastatic Merkel cell carcinoma, prostate cancer, liver cancer, bowel cancer, stomach cancer, multiple myeloma, mantle cell lymphoma, diffuse large B cell lymphoma liver cancer, Hodgkin lymphoma, chronic lymphocytic leukemia, squamous cell carcinoma, and the like.
Inventors:
ZHAO YUJUN (CN)
ZHU DI (CN)
ZHOU FEILONG (CN)
YAN ZIQIN (CN)
LIU CHENGLONG (CN)
ZHANG XICHEN (CN)
ZHU DI (CN)
ZHOU FEILONG (CN)
YAN ZIQIN (CN)
LIU CHENGLONG (CN)
ZHANG XICHEN (CN)
Application Number:
PCT/CN2020/094013
Publication Date:
December 10, 2020
Filing Date:
June 02, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
UNIV FUDAN (CN)
UNIV FUDAN (CN)
International Classes:
C07D319/10; A61K31/047; A61K31/36; A61K31/44; A61K31/4433; A61K31/4545; A61P35/00; C07D213/84; C07D407/12; C07D413/12; C07D413/14; C07H15/18; C07H15/26
Domestic Patent References:
| WO2020011246A1 | 2020-01-16 | |||
| WO2018044963A1 | 2018-03-08 |
Foreign References:
| CN110240587A | 2019-09-17 | |||
| CN105705489A | 2016-06-22 | |||
| US20180305315A1 | 2018-10-25 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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