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Title:
COMPOUNDS AFFECTING SAICAR SYNTHESIS, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/059214
Kind Code:
A1
Abstract:
Provided are compounds affecting SAICAR synthesis, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.

Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
Application Number:
CN2017/101062
Publication Date:
April 05, 2018
Filing Date:
September 08, 2017
Export Citation:
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Assignee:
GENEHEAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07H19/20; A61K31/198; A61K31/7072; A61K31/7076; A61K31/708; A61K38/07; A61P3/00; A61P25/00
Domestic Patent References:
WO1990001036A11990-02-08
WO2003062255A22003-07-31
WO2005020885A22005-03-10
Foreign References:
Other References:
MACKENZIE, G. ET AL.: "Synthesis of Analogues of 5 -Aminoimidazole Ribonucleotides and their Effects as Inhibitors and Substrates of the Enzymes, Phosphoribosylaminoimidazole Carboxylase and PhosphoribosylaminoimidazolesuccinocarboxamideSynthetase Involved in the Biosynthesis of Purine Nucleotides de novo", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. 12, 1 January 1976 (1976-01-01), pages 453 - 455, XP055500446
CHIPPERFIEL, J.R. ET AL.: "Effects on the Activity of the Enzyme Phosphoribosyl-Aminoimidazole Carboxylase, 5'-Phosphate", NUCLEOSIDES AND NUCLEOTIDES, vol. 7, no. 5-6, 31 December 1988 (1988-12-31), pages 571 - 576
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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