Title:
COMPOUNDS AS CATIONIC LIPIDS
Document Type and Number:
WIPO Patent Application WO/2017/111172
Kind Code:
A1
Abstract:
The present invention provides compounds represented by formula (I) as cationic lipids, or pharmaceutically-acceptable salts or the like thereof.
Inventors:
HOSOE SHINTARO (JP)
NAOI TOMOYUKI (JP)
NAOI TOMOYUKI (JP)
Application Number:
PCT/JP2016/088751
Publication Date:
June 29, 2017
Filing Date:
December 26, 2016
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
A61K31/397; C07D205/04; A61K31/40; A61K48/00; A61P35/00; A61P43/00; C12N15/113
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MAIER M. A. ET AL.: "Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics", MOLECULAR THERAPY, vol. 21, no. 8, 2013, pages 1570 - 1578, XP055237159, ISSN: 2372-7705
MOLECULAR THERAPY, vol. 21, 2013, pages 1570 - 1578
T.W. GREENE: "Protective Groups in Organic Synthesis, third edition,", 1999, JOHN WILEY & SONS INC.
"New Experimental Chemistry 14, Synthesis and Reaction of Organic Compound (II", 1977, MARUZEN CO., LTD.
"New Experimental Chemistry 14, Synthesis and Reaction of Organic Compound (II", 1977, MARUZEN CO., LTD., pages: 751
"New Experimental Chemistry 15, Oxidation and Reduction (II", 1977, MARUZEN CO., LTD.
J. AM. CHEM. SOC., vol. 124, no. 10, 2002, pages 2092
TETRAHEDRON LETTERS, vol. 38, no. 50, 1997, pages 8735 - 8738
TETRAHEDRON, vol. 54, no. 14, 1998, pages 3607 - 3630
NUCLEIC ACID RESEARCH, vol. 32, 2004, pages e175
ACC. CHEM. RES., vol. 32, 1999, pages 624
J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
BANGHAM ET AL., J. MOL. BIOL., vol. 13, 1965, pages 238 - 252
J. CELL BIOL., vol. 66, 1975, pages 621 - 634
FEBS LETT., vol. 99, 1979, pages 210 - 214
ARCH. BIOCHEM. BIOPHYS., vol. 212, 1981, pages 186 - 194
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 4194 - 4198
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1510, 2001, pages 152 - 166
D.D. LASIC; F. MARTIN: "Stealth Liposomes", 1995, CRC PRESS INC., pages: 93 - 102
R.H. MULLER, S. BENITA AND B. BOHM: "Emulsion and Nanosuspensions for the Formulation of Poorly Soluble Drugs", 1998, SCIENTIFIC PUBLISHERS, pages: 267 - 294
See also references of EP 3395797A4
MOLECULAR THERAPY, vol. 21, 2013, pages 1570 - 1578
T.W. GREENE: "Protective Groups in Organic Synthesis, third edition,", 1999, JOHN WILEY & SONS INC.
"New Experimental Chemistry 14, Synthesis and Reaction of Organic Compound (II", 1977, MARUZEN CO., LTD.
"New Experimental Chemistry 14, Synthesis and Reaction of Organic Compound (II", 1977, MARUZEN CO., LTD., pages: 751
"New Experimental Chemistry 15, Oxidation and Reduction (II", 1977, MARUZEN CO., LTD.
J. AM. CHEM. SOC., vol. 124, no. 10, 2002, pages 2092
TETRAHEDRON LETTERS, vol. 38, no. 50, 1997, pages 8735 - 8738
TETRAHEDRON, vol. 54, no. 14, 1998, pages 3607 - 3630
NUCLEIC ACID RESEARCH, vol. 32, 2004, pages e175
ACC. CHEM. RES., vol. 32, 1999, pages 624
J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
BANGHAM ET AL., J. MOL. BIOL., vol. 13, 1965, pages 238 - 252
J. CELL BIOL., vol. 66, 1975, pages 621 - 634
FEBS LETT., vol. 99, 1979, pages 210 - 214
ARCH. BIOCHEM. BIOPHYS., vol. 212, 1981, pages 186 - 194
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 4194 - 4198
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1510, 2001, pages 152 - 166
D.D. LASIC; F. MARTIN: "Stealth Liposomes", 1995, CRC PRESS INC., pages: 93 - 102
R.H. MULLER, S. BENITA AND B. BOHM: "Emulsion and Nanosuspensions for the Formulation of Poorly Soluble Drugs", 1998, SCIENTIFIC PUBLISHERS, pages: 267 - 294
See also references of EP 3395797A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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