Title:
COMPOUNDS AND COMPOSITIONS FOR ANITMALARIAL THERAPEUTIC AND PROPHYLACTIC USE
Document Type and Number:
WIPO Patent Application WO/2023/168107
Kind Code:
A3
Abstract:
Malaria still afflicts about half of the world population causing more than 400,000 deaths, mostly children. The options for malaria therapy are increasingly becoming limited because of widespread drug resistance. Furthermore, drugs for prophylaxis are suboptimal. This disclosure reports the identification of type II protein kinase inhibitor compounds which have never been explored as antimalarial agents and which now have been discovered to possess therapeutic and prophylactic properties against malaria.
Inventors:
CHAKRABARTI DEBOPAM (US)
BOHMER MONICA (US)
GRAY NATHANAEL (US)
WANG LUSHUN (US)
WANG JINHUA (US)
CALLA CHOQUE JAESON SANTOS (US)
WINZELER ELIZABETH (US)
BOHMER MONICA (US)
GRAY NATHANAEL (US)
WANG LUSHUN (US)
WANG JINHUA (US)
CALLA CHOQUE JAESON SANTOS (US)
WINZELER ELIZABETH (US)
Application Number:
PCT/US2023/014591
Publication Date:
December 07, 2023
Filing Date:
March 06, 2023
Export Citation:
Assignee:
UNIV CENTRAL FLORIDA RES FOUND INC (US)
DANA FARBER CANCER INST INC (US)
UNIV CALIFORNIA (US)
UNIV LELAND STANFORD JUNIOR (US)
DANA FARBER CANCER INST INC (US)
UNIV CALIFORNIA (US)
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
C07C233/80; C07C15/12; A61K31/166; A61K31/167; A61P31/00
Foreign References:
| US20160108051A1 | 2016-04-21 | |||
| US20160257642A1 | 2016-09-08 | |||
| US20190077768A1 | 2019-03-14 |
Other References:
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "AKOS033141983", XP093118416, retrieved from PUBCHEM
Attorney, Agent or Firm:
VAN DYKE, Timothy, H. et al. (US)
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