Title:
COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2005/107464
Kind Code:
A2
Abstract:
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
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Inventors:
LIU HONG (US)
TULLY DAVID C (US)
CHATTERJEE ARNAB (US)
ALPER PHILLIP B (US)
WOODMANSEE DAVID H (US)
MUTNICK DANIEL (US)
TULLY DAVID C (US)
CHATTERJEE ARNAB (US)
ALPER PHILLIP B (US)
WOODMANSEE DAVID H (US)
MUTNICK DANIEL (US)
Application Number:
PCT/US2005/015117
Publication Date:
November 17, 2005
Filing Date:
April 29, 2005
Export Citation:
Assignee:
IRM LLC (US)
LIU HONG (US)
TULLY DAVID C (US)
CHATTERJEE ARNAB (US)
ALPER PHILLIP B (US)
WOODMANSEE DAVID H (US)
MUTNICK DANIEL (US)
LIU HONG (US)
TULLY DAVID C (US)
CHATTERJEE ARNAB (US)
ALPER PHILLIP B (US)
WOODMANSEE DAVID H (US)
MUTNICK DANIEL (US)
International Classes:
A01N43/08; C07D211/66; C07D263/56; C07D273/02; C07D277/64; C07D295/185; C07D307/30; (IPC1-7): A01N43/08
Domestic Patent References:
| WO2002100849A2 | 2002-12-19 | |||
| WO2003105855A1 | 2003-12-24 | |||
| WO2003024924A1 | 2003-03-27 |
Foreign References:
| US6562827B1 | 2003-05-13 |
Other References:
INUI, T.; O. ISHIBASHI, J BIOL CHEM, vol. 272, no. 13, 1997, pages 8109 - 12
SAFTIG, P.; E. HUNZIKER ET AL., ADV EXP MED BIOL 2000+ADS, vol. 477, 2000, pages 293 - 303
SAFTIG, P.; E. HUNZIKER ET AL., PROC NATL ACAD SCI U S A, vol. 95, no. 23, 1998, pages 13453 - 8
JORMSJO, S.; D. M. WUTTGE ET AL., AM J PATHOL, vol. 161, no. 3, 2002, pages 939 - 45
BECK, H.; G. SCHWARZ ET AL., EUR J IMMUNOL, vol. 31, no. 12, 2001, pages 3726 - 36
NAKAGAWA, T. Y.; W. H. BRISSETTE ET AL., IMMUNITY, vol. 10, no. 2, 1999, pages 207 - 17
HOU, W. S.; Z. LI ET AL., AM J PATHOL, vol. 159, no. 6, 2001, pages 2167 - 77
CIMERMAN, N.; P. M. BRGULJAN ET AL., PFLUGERS ARCH, vol. 442, no. 6, 2001, pages R204 - 6
LEMERE, C. A.; J. S. MUNGER ET AL., AM J PATHOL, vol. 146, no. 4, 1995, pages 848 - 60
JEAN JACQUES; ANDRE COLLET; SAMUEL H. WILEN: "Enantiomers, Racemates and Resolutions", 1981, JOHN WILEY AND SONS, INC.
See also references of EP 1744755A4
SAFTIG, P.; E. HUNZIKER ET AL., ADV EXP MED BIOL 2000+ADS, vol. 477, 2000, pages 293 - 303
SAFTIG, P.; E. HUNZIKER ET AL., PROC NATL ACAD SCI U S A, vol. 95, no. 23, 1998, pages 13453 - 8
JORMSJO, S.; D. M. WUTTGE ET AL., AM J PATHOL, vol. 161, no. 3, 2002, pages 939 - 45
BECK, H.; G. SCHWARZ ET AL., EUR J IMMUNOL, vol. 31, no. 12, 2001, pages 3726 - 36
NAKAGAWA, T. Y.; W. H. BRISSETTE ET AL., IMMUNITY, vol. 10, no. 2, 1999, pages 207 - 17
HOU, W. S.; Z. LI ET AL., AM J PATHOL, vol. 159, no. 6, 2001, pages 2167 - 77
CIMERMAN, N.; P. M. BRGULJAN ET AL., PFLUGERS ARCH, vol. 442, no. 6, 2001, pages R204 - 6
LEMERE, C. A.; J. S. MUNGER ET AL., AM J PATHOL, vol. 146, no. 4, 1995, pages 848 - 60
JEAN JACQUES; ANDRE COLLET; SAMUEL H. WILEN: "Enantiomers, Racemates and Resolutions", 1981, JOHN WILEY AND SONS, INC.
See also references of EP 1744755A4
Attorney, Agent or Firm:
Reid, Scott W. (10675 John Jay Hopkins Drive San Diego, CA, US)
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