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Title:
COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2005/107464
Kind Code:
A2
Abstract:
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.

Inventors:
Liu, Hong (6348 Oleander Way, San Diego, CA, 92130, US)
Tully, David C. (4278 Calle Isabelino, San Diego, CA, 92130, US)
Chatterjee, Arnab (1007 Guadalajara, Encinitas, CA, 92024, US)
Alper, Phillip B. (12184 Pepper Tree Lane, Poway, CA, 92064, US)
Woodmansee, David H. (2966 Kobe Drive, San Diego, CA, 92123, US)
Mutnick, Daniel (2509 Old Quarry Road #1431, San Diego, CA, 92108, US)
Application Number:
PCT/US2005/015117
Publication Date:
November 17, 2005
Filing Date:
April 29, 2005
Export Citation:
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Assignee:
IRM LLC (P.O. Box HM 2899, Hamilton, HM LX, BM)
Liu, Hong (6348 Oleander Way, San Diego, CA, 92130, US)
Tully, David C. (4278 Calle Isabelino, San Diego, CA, 92130, US)
Chatterjee, Arnab (1007 Guadalajara, Encinitas, CA, 92024, US)
Alper, Phillip B. (12184 Pepper Tree Lane, Poway, CA, 92064, US)
Woodmansee, David H. (2966 Kobe Drive, San Diego, CA, 92123, US)
Mutnick, Daniel (2509 Old Quarry Road #1431, San Diego, CA, 92108, US)
International Classes:
A01N43/08; C07D211/66; C07D263/56; C07D273/02; C07D277/64; C07D295/185; C07D307/30; (IPC1-7): A01N43/08
Domestic Patent References:
WO2002100849A22002-12-19
WO2003105855A12003-12-24
WO2003024924A12003-03-27
Foreign References:
US6562827B12003-05-13
Other References:
INUI, T.; O. ISHIBASHI J BIOL CHEM vol. 272, no. 13, 1997, pages 8109 - 12
SAFTIG, P.; E. HUNZIKER ET AL. ADV EXP MED BIOL 2000+ADS vol. 477, 2000, pages 293 - 303
SAFTIG, P.; E. HUNZIKER ET AL. PROC NATL ACAD SCI U S A vol. 95, no. 23, 1998, pages 13453 - 8
JORMSJO, S.; D. M. WUTTGE ET AL. AM J PATHOL vol. 161, no. 3, 2002, pages 939 - 45
BECK, H.; G. SCHWARZ ET AL. EUR J IMMUNOL vol. 31, no. 12, 2001, pages 3726 - 36
NAKAGAWA, T. Y.; W. H. BRISSETTE ET AL. IMMUNITY vol. 10, no. 2, 1999, pages 207 - 17
HOU, W. S.; Z. LI ET AL. AM J PATHOL vol. 159, no. 6, 2001, pages 2167 - 77
CIMERMAN, N.; P. M. BRGULJAN ET AL. PFLUGERS ARCH vol. 442, no. 6, 2001, pages R204 - 6
LEMERE, C. A.; J. S. MUNGER ET AL. AM J PATHOL vol. 146, no. 4, 1995, pages 848 - 60
JEAN JACQUES; ANDRE COLLET; SAMUEL H. WILEN: 'Enantiomers, Racemates and Resolutions', 1981, JOHN WILEY AND SONS, INC.
See also references of EP 1744755A2
Attorney, Agent or Firm:
Reid, Scott W. (The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive San Diego, CA, 92121, US)
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