Title:
COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2016/105485
Kind Code:
A3
Abstract:
The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
Inventors:
BASTOS CECILIA M (US)
MUNOZ BENITO (US)
TAIT BRADLEY (US)
MUNOZ BENITO (US)
TAIT BRADLEY (US)
Application Number:
PCT/US2015/000212
Publication Date:
September 01, 2016
Filing Date:
December 23, 2015
Export Citation:
Assignee:
PROTEOSTASIS THERAPEUTICS INC (US)
International Classes:
C07D413/14; A61K31/341; A61K31/42; A61K31/422; C07D261/14; C07D307/54; C07D405/12; C07D407/12; C07D409/14; C07D413/12; C07D417/12; A61P11/00; A61P25/00
Domestic Patent References:
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| WO2003093297A2 | 2003-11-13 | |||
| WO2006014134A1 | 2006-02-09 | |||
| WO2010089297A1 | 2010-08-12 | |||
| WO2007126362A1 | 2007-11-08 | |||
| WO2010142801A1 | 2010-12-16 | |||
| WO2007086584A1 | 2007-08-02 | |||
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Foreign References:
| EP0957099A2 | 1999-11-17 | |||
| US5780393A | 1998-07-14 | |||
| JP2006176443A | 2006-07-06 | |||
| EP0337263A2 | 1989-10-18 |
Other References:
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NATHAN A. LACK ET AL: "Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 24, 22 December 2011 (2011-12-22), pages 8563 - 8573, XP055029952, ISSN: 0022-2623, DOI: 10.1021/jm201098n
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O.V. DEMINA ET AL.: "5-substituted pyridylisoxazoles as effective inhibitors of platelet aggregation", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 63, no. 2, September 2014 (2014-09-01), pages 2092 - 2113, XP002758751, ISSN: 1066-5285
NATHAN A. LACK ET AL: "Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 24, 22 December 2011 (2011-12-22), pages 8563 - 8573, XP055029952, ISSN: 0022-2623, DOI: 10.1021/jm201098n
CHANG, XIN-HONG: "3-(2-chlorophenyl)-N-methylisoxazole-5-carboxamide", ACTA CRYSTALLOGRAPHICA, SECTION E: STRUCTURE REPORTS ONLINE, vol. E63, no. 7, 2007, pages o3074 - sup-7, XP002758750, ISSN: 1600-5368, DOI: 10.1107/S1600536807025895
O.V. DEMINA ET AL.: "5-substituted pyridylisoxazoles as effective inhibitors of platelet aggregation", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 63, no. 2, September 2014 (2014-09-01), pages 2092 - 2113, XP002758751, ISSN: 1066-5285
Attorney, Agent or Firm:
KAVANAUGH, Theresa, C. et al. (Exchange PlaceBoston, MA, US)
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