Title:
COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY
Document Type and Number:
WIPO Patent Application WO2006034003
Kind Code:
A3
Abstract:
Compounds and compositions are provided for treatment or amelioration of one or more symptoms of a-synuclein toxicity, a-synuclein mediated diseases or diseases in which a-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
Inventors:
LINDQUIST SUSAN L (US)
OUTEIRO TIAGO (US)
LABAUDINIERE RICHARD (US)
OUTEIRO TIAGO (US)
LABAUDINIERE RICHARD (US)
Application Number:
PCT/US2005/033050
Publication Date:
July 13, 2006
Filing Date:
September 16, 2005
Export Citation:
Assignee:
WHITEHEAD BIOMEDICAL INST (US)
FOLDRX PHARMACEUTICALS INC (US)
LINDQUIST SUSAN L (US)
OUTEIRO TIAGO (US)
LABAUDINIERE RICHARD (US)
FOLDRX PHARMACEUTICALS INC (US)
LINDQUIST SUSAN L (US)
OUTEIRO TIAGO (US)
LABAUDINIERE RICHARD (US)
International Classes:
A61K31/415; A61K31/425; A61K31/42; A61K31/44
Foreign References:
| US20040067991A1 | 2004-04-08 |
Other References:
See also references of EP 1802303A4
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