Title:
COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING BETA-AMYLOID PRODUCTION
Document Type and Number:
WIPO Patent Application WO2002100836
Kind Code:
A3
Abstract:
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical composition including one or more agents that modulate PPAR alpha and/or PPARDelta activity, resulting in an inhibition of beta -amyloid production and/or release from cells of the subject, particularly brain cells.
Inventors:
CONNOP BRUCE P (CA)
GRANT AMELIA (CA)
NATHWANI PARIMAL S (CA)
GRANT AMELIA (CA)
NATHWANI PARIMAL S (CA)
Application Number:
PCT/CA2002/000863
Publication Date:
May 15, 2003
Filing Date:
June 12, 2002
Export Citation:
Assignee:
ACTIVE PASS PHARMACEUTICALS IN (CA)
CONNOP BRUCE P (CA)
GRANT AMELIA (CA)
NATHWANI PARIMAL S (CA)
CONNOP BRUCE P (CA)
GRANT AMELIA (CA)
NATHWANI PARIMAL S (CA)
International Classes:
C07D239/47; A61K31/216; A61K31/505; A61K38/00; A61K38/22; A61K38/28; A61K39/395; A61K45/00; A61P17/00; A61P25/28; C07C275/10; C07C275/16; C07C275/30; C07C275/34; C07D239/46; C07D405/12; (IPC1-7): C07D239/46; A61K31/505; A61P25/28; C07K14/485; C07K14/62
Domestic Patent References:
| WO2001003659A1 | 2001-01-18 | |||
| WO2000055318A2 | 2000-09-21 |
Foreign References:
| FR2344545A1 | 1977-10-14 | |||
| FR2182917A1 | 1973-12-14 | |||
| EP0073328A1 | 1983-03-09 | |||
| DE10053003A1 | 2001-06-28 |
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