Title:
COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PEPTIC ULCERS AND GASTROINTESTINAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2014/147541
Kind Code:
A3
Abstract:
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for the treatment of peptic ulcers and gastrointestinal diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of duodenal ulcers, esophageal ulcers, gastric ulcers, Meckel's diverticulum ulcers, gastroesophageal ulcers, Type I to Type V gastroesophageal ulcers, gastric reflux disease (GERD), peptic ulcers, gastrointestinal bleeding, inflammation, irritable bowel disease, Crohn's disease, gastritis, pancreatitis, stomach cancer, cholesystitis and hepatic congestion.
Inventors:
KANDULA MAHESH (IN)
Application Number:
PCT/IB2014/059866
Publication Date:
February 19, 2015
Filing Date:
March 16, 2014
Export Citation:
Assignee:
KANDULA MAHESH (IN)
International Classes:
A61K31/40; A61P1/04; C07C47/192; C07D207/12
Domestic Patent References:
| WO2002004402A1 | 2002-01-17 | |||
| WO2004018422A1 | 2004-03-04 | |||
| WO2014091384A2 | 2014-06-19 |
Foreign References:
| US2956062A | 1960-10-11 | |||
| EP0251126A2 | 1988-01-07 |
Other References:
FRANKO, BERNARD V. ET AL.: "Derivatives of 3-Pyrrolidinols--III. The Chemistry, Pharmacology, and Toxicology of some N-Substituted-3-Pyrrolidyl -Substitutes Phenylacetates.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 2, no. 5, 1959, pages 523 - 540
POSEY, E. L.: "Management of peptic ulcer with glycopyrrolate.", DIGESTIVE DISEASES AND SCIENCES, vol. 7, no. 10, 1962, pages 863 - 872
POSEY, E. L.: "Management of peptic ulcer with glycopyrrolate.", DIGESTIVE DISEASES AND SCIENCES, vol. 7, no. 10, 1962, pages 863 - 872
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