COMPOUNDS EFFECTING NEURON REMODELING AND ASSAYS FOR SAME

WIPO Patent Application WO2002064742

A3

The present invention provides agents that reduce apoE4 domain interaction. Agents of the invention are useful to treat disorders associated with apoE4. The present invention further provides pharmaceutical compositions comprising the agents. The present invention further provides methods of treating disorders associated with apoE4.

MAHLEY ROBERT W (US)
WEISGRABER KARL H (US)
PITAS ROBERT E (US)
HUANG YADONG (US)

PCT/US2002/004151

December 04, 2003

February 11, 2002

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DAVID GLADSTONE INST (US)
MAHLEY ROBERT W (US)
WEISGRABER KARL H (US)
PITAS ROBERT E (US)
HUANG YADONG (US)

A61K45/00; A61K38/17; A61K38/40; A61P25/28; C07K14/775; C07K16/18; C12N5/08; A61K38/00; (IPC1-7): A01N37/18; A01N61/00; A61K38/00; C07K1/00; C07K14/00; C07K16/00; C07K17/00; C12N5/08

DONG, J. ET AL.: "Human apolipoprotein E7: lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins", J. LIPID RESEARCH, vol. 41, 2000, pages 1783 - 1789, XP001018932
DONG, L.-M. ET AL.: "Human apolipoprotein E4 domain interaction", JOURNAL OF BIOL. CHEMISTRY, vol. 271, no. 32, 1996, pages 19053 - 19057, XP002953439
RAFFAI, R. ET AL.: "Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 20, 25 September 2001 (2001-09-25), pages 11587 - 11591, XP002953440
See also references of EP 1408753A4

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