Title:
COMPOUNDS FOR ENHANCING PPARγ EXPRESSION AND NUCLEAR TRANSLOCATION AND THERAPEUTIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/119701
Kind Code:
A1
Abstract:
The present invention relates to a novel type of PPARγ modulator having a pyrimido [5, 4-d]pyrimidine main structure. The PPARγ modulator can enhance the expression and nuclear translocation of PPARγ in cells. The present invention also relates to a pharmaceutical composition comprising the PPARγ modulator of the invention encapsulated in a pharmaceutically acceptable cell-penetrating drug delivery system so that it can be directly delivered into cells. The present invention thus provides a method of preventing or treating PPARγ-related disorders or conditions comprising administering to a subject in need thereof a therapeutically effective amount of the PPARγ modulator of the invention or the pharmaceutical composition of the invention.
Inventors:
LIN JEN CHENG (CN)
LIN CHUN-CHIEH (CN)
LEE HSU-TUNG (CN)
FAN YU-MING (CN)
TSAI JUI-CHI (CN)
DU YING-CHI (CN)
LIN CHUN-CHIEH (CN)
LEE HSU-TUNG (CN)
FAN YU-MING (CN)
TSAI JUI-CHI (CN)
DU YING-CHI (CN)
Application Number:
PCT/CN2016/072347
Publication Date:
August 04, 2016
Filing Date:
January 27, 2016
Export Citation:
Assignee:
REALINN LIFE SCIENCE LTD (CN)
International Classes:
A61K31/395; A61K9/127; A61K31/519; A61P1/16; A61P1/18; A61P3/00; A61P3/10; A61P9/00; A61P25/28; A61P37/00
Foreign References:
| US3031450A | 1962-04-24 | |||
| CN1481244A | 2004-03-10 |
Other References:
See also references of EP 3250201A4
Attorney, Agent or Firm:
LEE AND LI - LEAVEN IPR AGENCY LTD. (Tower A Beijing Marriott Center, No. 7, Jian Guo Men South Avenue,Dongcheng District, Beijing 5, CN)
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