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Title:
COMPOUNDS HAVING RORγt INHIBITORY EFFECTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2017/010399
Kind Code:
A1
Abstract:
Provided are compounds having RORγt inhibitory effects represented by formula (I). Compounds represented by formula (I) (wherein L represents -NR1ACO-, -SO2- or the like, A represents a substituted or unsubstituted aromatic carbocyclic group or the like, R1, R2, R3a, R4a, R3b and R4b represent hydrogen or substituted or unsubstituted alkyl or the like, m is from 0 to 2, n is 0 or 1, ring B represents an aromatic carbocyclic ring, an aromatic heterocyclic ring, etc., R1A represents hydrogen, etc., E represents SO2R10A, etc., R10A represents substituted or unsubstituted alkyl, etc., X represents =CR9- or =N-, R5 and R8 represent halogen, hydroxy, etc., R9 represents hydrogen, halogen, hydroxy, etc., R6 and R7 represent hydrogen, halogen, substituted or unsubstituted alkyl, etc., p is from 0 to 4 and q is from 0 to 3) or pharmaceutically acceptable salts thereof.

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Inventors:
TAKIYAMA, Kei (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
OHDAN, Masahide (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
SASAKI, Yoshikazu (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
KIDA, Shiro (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
TACHIBANA, Yuki (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
HATA, Kayoko (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
KATOU, Manabu (1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
Application Number:
JP2016/070151
Publication Date:
January 19, 2017
Filing Date:
July 07, 2016
Export Citation:
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Assignee:
SHIONOGI & CO., LTD. (1-8 Doshomachi 3-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
International Classes:
C07C317/28; A61K31/167; A61K31/343; A61K31/397; A61K31/403; A61K31/4168; A61K31/421; A61K31/426; A61K31/44; A61K31/445; A61K31/5375; A61P1/04; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; C07C317/30; C07C317/44; C07C317/46; C07D205/04; C07D205/12; C07D207/12; C07D209/04; C07D209/08; C07D209/34; C07D209/44; C07D209/46; C07D211/38; C07D211/46; C07D211/48; C07D213/71; C07D213/74; C07D213/75; C07D213/84; C07D215/08; C07D231/18; C07D231/56; C07D233/84; C07D233/88; C07D235/06; C07D235/14; C07D235/26; C07D237/18; C07D237/20; C07D241/20; C07D263/48; C07D263/56; C07D263/58; C07D265/36; C07D271/06; C07D271/10; C07D277/46; C07D277/64; C07D277/68; C07D295/12; C07D295/182; C07D295/22; C07D305/08; C07D307/78; C07D309/14; C07D319/18; C07D417/06; C07D471/04; C07D491/107; C07D498/04; C07D513/04
Domestic Patent References:
WO2015082533A12015-06-11
WO2015083130A12015-06-11
WO2009010478A22009-01-22
WO2015145371A12015-10-01
WO2015116904A12015-08-06
Other References:
YANG T ET AL: "Discovery of Tertiary Amine and Indole Derivatives as Potent ROR-gamma-t Inverse Agonists", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 1, 2014, pages 65 - 68, XP002730929
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (Shionogi & Co, Ltd. Intellectual Property Department 1-1, Futabacho 3-chome, Toyonaka-sh, Osaka 25, 〒5610825, JP)
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