Title:
COMPOUNDS HAVING CDK4/6 KINASE INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/170055
Kind Code:
A1
Abstract:
The present invention relates to compounds having CDK4/6 kinase inhibitory activity, a pharmaceutical composition thereof and a use thereof. The present invention relates in particular to compounds represented by formula I, and further relates to a pharmaceutical composition comprising such compounds and a method for using such compounds in the prevention or treatment of diseases, especially for use with diseases mediated by CDK kinase, in particular by CDK4/6 kinase aberrant activity.
Inventors:
ZHA CHUANTAO (CN)
GENG MEIYU (CN)
HUANG YING (CN)
DING JIAN (CN)
WAN HUIXIN (CN)
HUANG MIN (CN)
FU YAN (CN)
TANG SHUAI (CN)
YE YAN (CN)
LAN XIAOJING (CN)
CHEN YI (CN)
GENG MEIYU (CN)
HUANG YING (CN)
DING JIAN (CN)
WAN HUIXIN (CN)
HUANG MIN (CN)
FU YAN (CN)
TANG SHUAI (CN)
YE YAN (CN)
LAN XIAOJING (CN)
CHEN YI (CN)
Application Number:
PCT/CN2019/076864
Publication Date:
September 12, 2019
Filing Date:
March 04, 2019
Export Citation:
Assignee:
SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D471/04; A61K31/506; A61P35/00; C07D231/56; C07D263/58; C07D403/04; C07D413/04; C07D519/00
Domestic Patent References:
| WO2018121766A1 | 2018-07-05 |
Foreign References:
| CN106188038A | 2016-12-07 | |||
| CN106810536A | 2017-06-09 | |||
| CN105294683A | 2016-02-03 |
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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