Title:
COMPOUNDS FOR INHIBITING OR DECOMPOSING CDK2 AND/OR CDK9, AND MEDICINAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/039210
Kind Code:
A1
Abstract:
The present invention provides: compounds having a specific chemical structure and having the activity of inhibiting or decomposing CDK2 and/or CDK9, or pharmaceutically acceptable salts thereof; and a method for preparing same. The present invention provides a composition comprising the compounds or pharmaceutically acceptable salts thereof. The present invention provides: a use of the compounds, salts thereof, and composition comprising same according to the present invention for inhibiting or decomposing CDK2 and/or CDK9; and medicinal uses for preventing or treating diseases associated with same. The present invention also provides a method for preventing or treating CDK2 and/or CDK9-related diseases, the method comprising administering, to an individual in need of treatment, an effective amount of the compounds, salts thereof, or composition comprising same according to the present invention.
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Inventors:
HWANG JONG YEON (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KIM PILHO (KR)
PARK CHI HOON (KR)
KIM HYUN JIN (KR)
KIM JEONG HOON (KR)
CHO JIN HWA (KR)
PARK BYOUNG CHUL (KR)
PARK SUNG GOO (KR)
KIM JUNG-AE (KR)
CHOI JI HOON (KR)
LEE HYE YEON (KR)
LEE YUJIN (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KIM PILHO (KR)
PARK CHI HOON (KR)
KIM HYUN JIN (KR)
KIM JEONG HOON (KR)
CHO JIN HWA (KR)
PARK BYOUNG CHUL (KR)
PARK SUNG GOO (KR)
KIM JUNG-AE (KR)
CHOI JI HOON (KR)
LEE HYE YEON (KR)
LEE YUJIN (KR)
Application Number:
PCT/KR2023/012222
Publication Date:
February 22, 2024
Filing Date:
August 17, 2023
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07D473/34; A61K31/52; A61P31/18; A61P35/00
Domestic Patent References:
| WO2013106643A2 | 2013-07-18 |
Foreign References:
| KR101893879B1 | 2018-09-03 | |||
| KR20210003804A | 2021-01-12 |
Other References:
SUN JUN PARK, EUNJIN KIM, MIYOUN YOO, JOO-YOUN LEE, CHI HOON PARK, JONG YEON HWANG, JAE DU HA: "Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 18, 1 September 2017 (2017-09-01), Amsterdam NL , pages 4399 - 4404, XP055753831, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.08.018
WU TIZHI, QIN ZHEN, TIAN YUCHENG, WANG JUBO, XU CHENXI, LI ZHIYU, BIAN JINLEI: "Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 22, 25 November 2020 (2020-11-25), US , pages 13228 - 13257, XP093140755, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00744
WU TIZHI, QIN ZHEN, TIAN YUCHENG, WANG JUBO, XU CHENXI, LI ZHIYU, BIAN JINLEI: "Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 22, 25 November 2020 (2020-11-25), US , pages 13228 - 13257, XP093140755, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00744
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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