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Title:
COMPOUNDS FOR INHIBITING LRRK2 KINASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/137618
Kind Code:
A1
Abstract:
Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical compositions comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.

Inventors:
REN FENG (CN)
SANG YINGXIA (CN)
XING WEIQIANG (CN)
ZHAN YANG (CN)
ZHAO BAOWEI (CN)
Application Number:
PCT/CN2018/073833
Publication Date:
August 02, 2018
Filing Date:
January 23, 2018
Export Citation:
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Assignee:
GLAXOSMITHKLINE IP DEV LTD (GB)
GLAXOSMITHKLINE CHINA R&D COMPANY LTD (CN)
International Classes:
C07D231/56; A61K31/416; A61P25/14; A61P25/16; A61P25/28
Domestic Patent References:
WO2016036586A12016-03-10
WO2017012576A12017-01-26
WO2016036586A12016-03-10
WO2017012576A12017-01-26
WO2014134772A12014-09-12
WO2014134774A12014-09-12
Foreign References:
CN105980388A2016-09-28
Other References:
See also references of EP 3573955A4
ZHANG FR ET AL., N ENGL J MED., vol. 361, 2009, pages 2609 - 18
BARRETT ET AL., NATURE GENETICS, vol. 40, 2008, pages 955 - 962
GARDET ET AL., J. IMMUNOLOGY, vol. 185, 2010, pages 5577 - 5585
MAEKAWA ET AL., BBRC, vol. 392, 2010, pages 431 - 435
RAY ET AL., J. IMMUNOL., vol. 230, 2011, pages 109
ENGEL ET AL., PHARMACOL. REV., vol. 63, 2011, pages 127 - 156
HOMAM ET AL., J. CLIN. NEUROMUSCULAR DISEASE, vol. 12, 2010, pages 91 - 102
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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