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Title:
COMPOUNDS INTERFERING WITH SAICAR SYNTHESIS, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/059213
Kind Code:
A1
Abstract:
Provided are compounds interfering with SAICAR synthesis, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.

Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
Application Number:
CN2017/101061
Publication Date:
April 05, 2018
Filing Date:
September 08, 2017
Export Citation:
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Assignee:
GENEHEAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C209/00; A61K31/00; A61K38/17; A61P25/08; A61P43/00; C07C221/00; C07C249/00; C07D405/14; C07D501/57; C07F9/90
Domestic Patent References:
WO2009151569A22009-12-17
WO2014067038A12014-05-08
Foreign References:
CN103748091A2014-04-23
CN101205555A2008-06-25
Other References:
JURECKA AGNIESZKA ET AL.: "Adenylosuccinate lyase deficiency", J INHERIT METAB DIS., vol. 38, no. 2, 12 August 2014 (2014-08-12), pages 231 - 242, XP035457180
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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