Title:
COMPOUNDS AND METHODS FOR ENHANCING ERYTHROPOIESIS
Document Type and Number:
WIPO Patent Application WO/2010/075263
Kind Code:
A3
Abstract:
Compounds and methods for enhancing erythropoiesis are disclosed. The compound comprises a chemical structure of the formula (I) indicated below, in which R is a glycosyl group. In addition to having an erythropoiesis effect, the compound of the formula (I) is effective in enhancing erythropoietin formation, increasing kidney function and the expression of hepatocyte growth factor. The method includes the step of administering an effective amount of the compound of the formula (I) to a subject in need thereof and thereby enhancing erythropoiesis.
Inventors:
WU RONG-TSUN (CN)
Application Number:
PCT/US2009/068957
Publication Date:
August 19, 2010
Filing Date:
December 21, 2009
Export Citation:
Assignee:
WU SOPHIA SHU FEN (US)
WU RONG-TSUN (CN)
WU RONG-TSUN (CN)
International Classes:
A61K31/7034; A61P1/00; A61P1/16; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P37/08; A61P43/00
Foreign References:
| US20050042314A1 | 2005-02-24 |
Other References:
ZHANG WEI ET AL: "Treatment with 2,3,4',5-tetrahydroxystilbene-2-O-.beta.-D-glucoside in atherosclerosis in rats", ZHONGGUO YAOKE DAXUE XUEBAO - JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, NANJING, CN, vol. 38, no. 3, 1 January 2007 (2007-01-01), pages 261 - 264, XP008119057, ISSN: 1000-5048
JIA XIN ET AL: "Neuroprotective effect of tetrahydroxystilbene glucoside on the rat model of Parkinson 's disease", ZHONGGUO XIN YAO ZAZHI - CHINESE NEW DRUGS JOURNAL, GAI-KAN BIANJIBU, BEIJING, CN, vol. 17, no. 9, 1 January 2008 (2008-01-01), pages 748 - 752, XP008119058, ISSN: 1003-3734
DATABASE WPI Week 200163, Derwent World Patents Index; AN 2001-558353, XP002569662
WANG ET AL: "Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-gluco side, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 578, no. 2-3, 25 October 2007 (2007-10-25), pages 339 - 348, XP022405039, ISSN: 0014-2999
KIMURA Y ET AL: "EFFECTS OF NATURALLY OCCURRING STILBENE GLUCOSIDES FROM MEDICINAL PLANTS AND WINE, ON TUNOUR GROWTH AND LUNG METASTASIS IN LEWIS LUNG CARCINOMA-BEARING MICE", JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOCIETY OF GREAT BRITAIN, GB, vol. 10, no. 52, 1 October 2000 (2000-10-01), pages 1287 - 1295, XP001069866, ISSN: 0022-3573
JIA XIN ET AL: "Neuroprotective effect of tetrahydroxystilbene glucoside on the rat model of Parkinson 's disease", ZHONGGUO XIN YAO ZAZHI - CHINESE NEW DRUGS JOURNAL, GAI-KAN BIANJIBU, BEIJING, CN, vol. 17, no. 9, 1 January 2008 (2008-01-01), pages 748 - 752, XP008119058, ISSN: 1003-3734
DATABASE WPI Week 200163, Derwent World Patents Index; AN 2001-558353, XP002569662
WANG ET AL: "Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-gluco side, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 578, no. 2-3, 25 October 2007 (2007-10-25), pages 339 - 348, XP022405039, ISSN: 0014-2999
KIMURA Y ET AL: "EFFECTS OF NATURALLY OCCURRING STILBENE GLUCOSIDES FROM MEDICINAL PLANTS AND WINE, ON TUNOUR GROWTH AND LUNG METASTASIS IN LEWIS LUNG CARCINOMA-BEARING MICE", JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOCIETY OF GREAT BRITAIN, GB, vol. 10, no. 52, 1 October 2000 (2000-10-01), pages 1287 - 1295, XP001069866, ISSN: 0022-3573
Attorney, Agent or Firm:
SAUNDERS, Hsiu-Ming (Inc.299 Old County Road, Suite 2, San Carlos California, US)
Download PDF: