Title:
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2014/100620
Kind Code:
A3
Abstract:
Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.
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Inventors:
WU GUOXIAN (US)
CHAN KATRINA (US)
EWING TODD (US)
IBRAHIM PRABHA N (US)
LIN JACK (US)
NESPI MARIKA (US)
SPEVAK WAYNE (US)
ZHANG YING (US)
CHAN KATRINA (US)
EWING TODD (US)
IBRAHIM PRABHA N (US)
LIN JACK (US)
NESPI MARIKA (US)
SPEVAK WAYNE (US)
ZHANG YING (US)
Application Number:
PCT/US2013/076995
Publication Date:
August 21, 2014
Filing Date:
December 20, 2013
Export Citation:
Assignee:
PLEXXIKON INC (US)
International Classes:
A61K31/437; C07D403/12; A61P35/00; C07D401/12; C07D471/04; C07D487/04; C07D513/04
Domestic Patent References:
| WO2008144253A1 | 2008-11-27 | |||
| WO2005094805A1 | 2005-10-13 | |||
| WO2000027394A1 | 2000-05-18 |
Foreign References:
| US20060035921A1 | 2006-02-16 | |||
| US7846941B2 | 2010-12-07 | |||
| US20070072862A1 | 2007-03-29 | |||
| EP2522658A1 | 2012-11-14 |
Other References:
DAVID L SELWOOD ET AL: "Solution-phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 8, 1 April 2001 (2001-04-01), pages 1089 - 1092, XP055118885, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)00141-X
FRANCOIS CLEMENCE ET AL: "4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 7, 1 July 1988 (1988-07-01), pages 1453 - 1462, XP055118870, ISSN: 0022-2623, DOI: 10.1021/jm00402a034
KISELYOV ET AL: "Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 13, 1 July 2007 (2007-07-01), pages 3550 - 3557, XP022114537, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.04.042
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 November 2010 (2010-11-22), XP002724645, Database accession no. 1253912-30-9
FRANCOIS CLEMENCE ET AL: "4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 7, 1 July 1988 (1988-07-01), pages 1453 - 1462, XP055118870, ISSN: 0022-2623, DOI: 10.1021/jm00402a034
KISELYOV ET AL: "Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 13, 1 July 2007 (2007-07-01), pages 3550 - 3557, XP022114537, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.04.042
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 November 2010 (2010-11-22), XP002724645, Database accession no. 1253912-30-9
Attorney, Agent or Firm:
TANNER, Lorna, L. et al. (379 Lytton AvenuePalo Alto, CA, US)
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