Title:
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/019804
Kind Code:
A3
Abstract:
Compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein A, J, R1, R2, R3, R4, R5, R6, R7, R9, X, m and n are as described herein, compositions thereof, and methods and uses thereof.
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Inventors:
HOLLADAY MARK W (US)
LIU GANG (US)
LIU GANG (US)
Application Number:
PCT/US2016/044330
Publication Date:
March 09, 2017
Filing Date:
July 27, 2016
Export Citation:
Assignee:
PLEXXIKON INC (US)
International Classes:
A61K31/4439; C07D413/14; C07B59/00; C07D417/14; C07D471/04; C07D487/04
Domestic Patent References:
| WO2011022473A1 | 2011-02-24 | |||
| WO2015031613A1 | 2015-03-05 |
Other References:
CHIUNG-TONG CHEN ET AL: "Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., vol. 100, 1 July 2015 (2015-07-01), FR, pages 151 - 161, XP055324553, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.05.008
LIU GANG ET AL: "Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 17, 14 July 2015 (2015-07-14), pages 3436 - 3441, XP029249485, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2015.07.023
LIU GANG ET AL: "Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 17, 14 July 2015 (2015-07-14), pages 3436 - 3441, XP029249485, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2015.07.023
Attorney, Agent or Firm:
TANNER, Lorna L. et al. (US)
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