Title:
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS
Document Type and Number:
WIPO Patent Application WO/2021/018118
Kind Code:
A1
Abstract:
The present invention relates to compounds comprising an interleukin-1 receptor-associated kinase 1 (IRAK1) protein binding moiety and a Von Hippel-Lindau (VHL) E3 ubiquitin ligase binding moiety, and associated methods of use. The compounds are useful as modulators of targeted ubiquitination, especially with respect to IRAK1, which is degraded by the compounds according to the invention.
Inventors:
FU LIQIANG (CN)
ZHANG JING (CN)
TU WANGYANG (CN)
LIU YINGTAO (CN)
KONG LINGLONG (CN)
SHEN BIN (CN)
DAI XUEDONG (CN)
XU YANPING (CN)
ZHANG JING (CN)
TU WANGYANG (CN)
LIU YINGTAO (CN)
KONG LINGLONG (CN)
SHEN BIN (CN)
DAI XUEDONG (CN)
XU YANPING (CN)
Application Number:
PCT/CN2020/105067
Publication Date:
February 04, 2021
Filing Date:
July 28, 2020
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
International Classes:
C07D401/14; A61K31/395; A61P29/00; A61P35/00
Domestic Patent References:
| WO2019099926A1 | 2019-05-23 | |||
| WO2018102725A1 | 2018-06-07 | |||
| WO2019006126A1 | 2019-01-03 |
Other References:
WANG， LI ET AL.: "Crystal structure of human IRAK1", PNAS, vol. 114, no. 51, 19 December 2017 (2017-12-19), pages 1 - 6, XP055777606
BUCKLEY， GEORGE M.ET AL.: "IRAK-4 inhibitors. Part 1: A series of amides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 26 April 2008 (2008-04-26), pages 3211 - 3214, XP022711199
BUCKLEY， GEORGE M.ET AL.: "IRAK-4 inhibitors. Part 1: A series of amides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 26 April 2008 (2008-04-26), pages 3211 - 3214, XP022711199
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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