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Title:
COMPOUNDS AND METHODS FOR TREATMENT OF EGF RECEPTOR ASSOCIATED CANCERS AND PURIFICATION OF THE EGF RECEPTOR
Document Type and Number:
WIPO Patent Application WO1997003701
Kind Code:
A3
Abstract:
The present invention discloses carbohydrates and carbohydrate analogs that bind to epidermal growth factor (EGF) receptors. Methods of using such carbohydrates or analogs for a variety of uses related to the EGF receptor are also provided. In preferred aspects of the present invention, methods for killing or inhibiting the growth of tumor cells with increased EGF receptor activity are disclosed.

Inventors:
MAGNANI JOHN L (US)
BREMER ERIC G (US)
Application Number:
PCT/US1996/011404
Publication Date:
April 17, 1997
Filing Date:
July 12, 1996
Export Citation:
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Assignee:
GLYCOTECH CORP (US)
MAGNANI JOHN L (US)
International Classes:
A61K9/127; A61K31/70; G01N33/566; A61K31/7008; A61K31/7012; A61K31/7028; A61K47/48; A61P35/00; C07H5/04; C07H7/027; C07H15/00; C07K14/71; C08G85/00; G01N33/15; (IPC1-7): A61K47/48; C07K14/71
Domestic Patent References:
WO1996021038A11996-07-11
Foreign References:
US5034516A1991-07-23
EP0368131A21990-05-16
US5401723A1995-03-28
Other References:
HATTORI M ET AL: "Sialyllactose -mediated cell interaction during granulosa cell differentiation. Identification of its binding proteins.", J BIOL CHEM, 7-4-1995, VOL. 270, NO. 14, PAGE(S) 7858-63, XP000644684
KIJIMA-SUDA I ET AL: "POSSIBLE MECHANISM OF INHIBITION OF EXPERIMENTAL PULMONARY METASTASIS OF MOUSE COLON ADENOCARCINOMA 26 SUBLINES BY A SIALIC ACID NUCLEOSIDE CONJUGATE", CANCER RES, VOL. 48, NO. 13, PAGE(S) 3728-3732, 1988, XP000618639
TOKOVENKO I P ET AL: "Inhibition of Mycoplasma pneumoniae adhesion in the fetuinic test system by synthetic analogues and polymeric forms of neuraminic acids.", MIKROBIOLOGICHESKII ZHURNAL (KIEV), VOL. 56, NO. 1, PUBL. 1994, PAGE(S) 3-9., XP002026326
SCHAUER, ROLAND ET AL: "The anti-recognition function of sialic acids: studies with erythrocytes and macrophages", PURE APPL. CHEM., VOL. 56, NO. 7, PAGES 907-21, 1984, XP000618595
J. DOWNWARD ET AL.: "Close similarity of epodermal growth factor receptor and v-erb-B oncogene protein sequences.", NATURE, vol. 307, 9 February 1984 (1984-02-09), LONDON GB, pages 521 - 527, XP002026327
YARDEN, YOSEF ET AL: "Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies", J. BIOL. CHEM., VOL. 260, NO. 1, PAGE(S) 315-19, 1985, XP002026328
PATENT ABSTRACTS OF JAPAN vol. 012, no. 288 (P - 741) 8 August 1988 (1988-08-08)
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