Title:
COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2021/000297
Kind Code:
A1
Abstract:
Disclosed herein relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R 1 are as defined herein. Disclosed herein also relates to compositions which comprise at least one dihydroisoxazole compound. Disclosed herein also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of a dihydroisoxazole of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
Inventors:
CROWLEY BRENDAN M (US)
NANTERMET PHILIPPE (US)
OLSEN DAVID (US)
SUZUKI TAKAO (CN)
NANTERMET PHILIPPE (US)
OLSEN DAVID (US)
SUZUKI TAKAO (CN)
Application Number:
PCT/CN2019/094601
Publication Date:
January 07, 2021
Filing Date:
July 03, 2019
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
CROWLEY BRENDAN M (US)
NANTERMET PHILIPPE (US)
OLSEN DAVID (US)
SUZUKI TAKAO (CN)
CROWLEY BRENDAN M (US)
NANTERMET PHILIPPE (US)
OLSEN DAVID (US)
SUZUKI TAKAO (CN)
International Classes:
C07D261/04; A61K31/42; A61P31/04; C07D413/10
Domestic Patent References:
| WO1998007708A1 | 1998-02-26 | |||
| WO1999041244A1 | 1999-08-19 |
Foreign References:
| CN101220000A | 2008-07-16 |
Other References:
DATABASE Registry 13 February 2017 (2017-02-13), ANONYMOUS: "2020_0048_Structure", XP009526136, retrieved from Registry
MICHAEL R BARBACHYN , GARY J CLEEK , LESTER A DOLAK , STUART A GARMON , JOEL MORRIS , ERIC P SEEST , RICHARD C THOMAS , DANA S TOO: "Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 1 January 2003 (2003-01-01), pages 284 - 302, XP002412110, ISSN: 0022-2623, DOI: 10.1021/jm020248u
MICHAEL R BARBACHYN , GARY J CLEEK , LESTER A DOLAK , STUART A GARMON , JOEL MORRIS , ERIC P SEEST , RICHARD C THOMAS , DANA S TOO: "Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 1 January 2003 (2003-01-01), pages 284 - 302, XP002412110, ISSN: 0022-2623, DOI: 10.1021/jm020248u
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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