COMPOUNDS FOR MODULATING FXR - NANJING RUIJIE PHARMA CO LTD

Title:

COMPOUNDS FOR MODULATING FXR

Document Type and Number:

WIPO Patent Application WO/2020/249064

Kind Code:

A1

Abstract:

Provided herein are compounds of Formula (I), a stereoisomer, enantiomer or a pharmaceutically acceptable salt thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

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Inventors:

ZHANG JUNBO (CN)
ZHU SHUHAO (CN)
QI XIAOXIN (CN)

Application Number:

PCT/CN2020/095754

Publication Date:

December 17, 2020

Filing Date:

June 12, 2020

Export Citation:

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Assignee:

NANJING RUIJIE PHARMA CO LTD (CN)

International Classes:

C07D413/12; A61K31/422; A61P1/16; A61P3/00; C07D413/14

Domestic Patent References:

WO2009005998A1	2009-01-08
WO2000037077A1	2000-06-29
WO2004048349A1	2004-06-10
WO2003015777A1	2003-02-27

Other References:

AKWABI-AMEYAW，A. ET AL.: "FXR agonist activity of conformationally constrained analogs of GW 4064.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 21 June 2009 (2009-06-21), pages 4733 - 4739, XP026419067, DOI: 20200901171932X

Attorney, Agent or Firm:

NANJING CIPIC INTELLECTUAL PROPERTY FIRM (GENERAL PARTNERSHIP) (CN)

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