Title:
COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEGATIVE-SENSE SSRNA VIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2011/000566
Kind Code:
A3
Abstract:
The present invention relates to novel compounds and pharmaceutical compositions and the use thereof for the manufacture of a medicament for treating, ameliorating, or preventing disease conditions caused by a viral infection with negative-sense ssRNA viruses.
Inventors:
CLASSEN-HOUBEN DIRK (AT)
SZOLAR OLIVER (AT)
SEHR PETER (DE)
WENDT BERND (DE)
GULLIGAY DELPHINE (FR)
CUSACK STEPHEN (FR)
LEWIS JOE (DE)
SZOLAR OLIVER (AT)
SEHR PETER (DE)
WENDT BERND (DE)
GULLIGAY DELPHINE (FR)
CUSACK STEPHEN (FR)
LEWIS JOE (DE)
Application Number:
PCT/EP2010/003967
Publication Date:
May 26, 2011
Filing Date:
June 30, 2010
Export Citation:
Assignee:
SAVIRA PHARMACEUTICALS GMBH (AT)
EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE)
CLASSEN-HOUBEN DIRK (AT)
SZOLAR OLIVER (AT)
SEHR PETER (DE)
WENDT BERND (DE)
GULLIGAY DELPHINE (FR)
CUSACK STEPHEN (FR)
LEWIS JOE (DE)
EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE)
CLASSEN-HOUBEN DIRK (AT)
SZOLAR OLIVER (AT)
SEHR PETER (DE)
WENDT BERND (DE)
GULLIGAY DELPHINE (FR)
CUSACK STEPHEN (FR)
LEWIS JOE (DE)
International Classes:
C07D295/18; A61K31/121; A61K31/136; A61K31/18; A61K31/437; A61K31/495; A61P31/14; A61P31/16; C07C49/78; C07C49/84; C07C205/46; C07C211/56; C07C243/28; C07C311/51; C07D471/04
Domestic Patent References:
| WO1999030710A1 | 1999-06-24 | |||
| WO2006083271A2 | 2006-08-10 | |||
| WO2006110762A2 | 2006-10-19 | |||
| WO2007076161A2 | 2007-07-05 | |||
| WO2008082484A1 | 2008-07-10 |
Foreign References:
| US20070010455A1 | 2007-01-11 |
Other References:
SANGHVI, YOGESH S. ET AL: "Synthesis and biological evaluation of certain C-4 substituted pyrazolo[3,4-b]pyridine nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 5, 1989, pages 945 - 951, XP002614401
DORSEY, BRUCE D. ET AL: "Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 18, 2000, pages 3386 - 3399, XP002614402
ATTABY, FAWZY ET AL: "Synthesis, Reactions, and Antiviral Activity of 1-(1H-Pyrazolo[3,4-b]pyridin-5-yl)ethanone and Pyrido[2',3':3,4]pyrazolo[5,1-c][1,2,4]triazine Derivatives", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 181, no. 5, 2010, pages 1087 - 1102, XP008130501
RYABUKHIN, SERGEY V. ET AL: "Chlorotrimethylsilane-mediated synthesis of functionalized fused pyridines: reaction of 3-formylchromones with electron-rich aminoheterocycles", SYNTHESIS, vol. 12, 2007, pages 1861 - 1871, XP002614405
LACOVA, MARGITA ET AL: "3-formylchromones IV. The rearrangement of 3-formylchromone enamines as a simple, facile route to novel pyrazolo[3,4-b]pyridines and the synthetic utility of the latter", MOLECULES, vol. 10, no. 7, 2005, pages 809 - 821, XP002614406
DORSEY, BRUCE D. ET AL: "Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 18, 2000, pages 3386 - 3399, XP002614402
ATTABY, FAWZY ET AL: "Synthesis, Reactions, and Antiviral Activity of 1-(1H-Pyrazolo[3,4-b]pyridin-5-yl)ethanone and Pyrido[2',3':3,4]pyrazolo[5,1-c][1,2,4]triazine Derivatives", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 181, no. 5, 2010, pages 1087 - 1102, XP008130501
RYABUKHIN, SERGEY V. ET AL: "Chlorotrimethylsilane-mediated synthesis of functionalized fused pyridines: reaction of 3-formylchromones with electron-rich aminoheterocycles", SYNTHESIS, vol. 12, 2007, pages 1861 - 1871, XP002614405
LACOVA, MARGITA ET AL: "3-formylchromones IV. The rearrangement of 3-formylchromone enamines as a simple, facile route to novel pyrazolo[3,4-b]pyridines and the synthetic utility of the latter", MOLECULES, vol. 10, no. 7, 2005, pages 809 - 821, XP002614406
Attorney, Agent or Firm:
VOSSIUS, Volker et al. (München, DE)
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