Title:
COMPOUNDS, PREPARATION PROCESS, AND USES THEREOF USED FOR INTERRUPTING REUPTAKE OF 5-HYDROXYTRYPTAMINE AND NOREPINEPHRINE OR TREATING DISEASES SUCH AS DEPRESSION ET AL.
Document Type and Number:
WIPO Patent Application WO/2006/133652
Kind Code:
A1
Abstract:
Compounds of the general formula (I), optical isomers, pharmaceutically acceptable salts, preparation process and uses thereof in which R1, R2, R3 and R4 are as defined in specification are disclosed. Such compounds can be optical isomers or racemic mixtures and can be metabolically transformated into 1-[2-dimethylamine-1-(4-hydroxyphenyl)-ethyl]cyclohexanol with new pharmaceutically active in vivo after administration, which can be used for treating diseases associated central nervous system such as depression et al. by interrupting reuptake of 5-hydroxytryptamine (5-HT ) and norepinephrine (NA ) .
Inventors:
ZHANG LUPING (CN)
Application Number:
PCT/CN2006/001370
Publication Date:
December 21, 2006
Filing Date:
June 16, 2006
Export Citation:
Assignee:
ZHANG LUPING (CN)
International Classes:
C07C215/42; A61K31/222; A61P25/00; C07C217/60; C07C219/24
Domestic Patent References:
| WO2003042162A1 | 2003-05-22 |
Foreign References:
| CN1706813A | 2005-12-14 | |||
| US6348494B1 | 2002-02-19 | |||
| US6673838B2 | 2004-01-06 | |||
| US4535186A | 1985-08-13 | |||
| US20040176468A1 | 2004-09-09 | |||
| US20040147601A1 | 2004-07-29 | |||
| US20030191347A1 | 2003-10-09 | |||
| US20040181093A1 | 2004-09-16 | |||
| CN1706813A | 2005-12-14 | |||
| US6348494B1 | 2002-02-19 |
Other References:
YANG H.-J. ET AL.: "Effect of gabapentin derivatives on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 10, 2004, pages 2537 - 2541, XP001183105
See also references of EP 1897867A4
YARDELEY ET AL., J MED CHEM, vol. 33, 1990, pages 2899 - 2905
See also references of EP 1897867A4
YARDELEY ET AL., J MED CHEM, vol. 33, 1990, pages 2899 - 2905
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza 2 Fuchengmenwai Street, Beijing 7, CN)
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