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Title:
COMPOUNDS REDUCING SAICAR ACCUMULATION, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/059215
Kind Code:
A1
Abstract:
Disclosed are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.

Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
Application Number:
CN2017/101064
Publication Date:
April 05, 2018
Filing Date:
September 08, 2017
Export Citation:
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Assignee:
GENEHEAL BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/7076; A61K31/43; A61K31/661; A61K38/05; A61P3/00; A61P25/08; A61P25/14
Domestic Patent References:
WO2003037371A22003-05-08
Foreign References:
US20160369281A12016-12-22
Other References:
ZIKANOVA M. ET AL.: "Preparation of 5-amino-4-imidazole-N-succinocarboxami- de ribotide, 5-amino-4-imidazole-N-succinocarboxamide riboside and succin- yladenosine, compounds usable in diagnosis and research of adenylosuccinate lyase deficiency", JOURNAL OF INHERITED METABOLIC DISEASE, vol. 28, no. 4, 1 June 2005 (2005-06-01) - 31 December 2015 (2015-12-31), pages 493 - 499, XP019232615, ISSN: 1573-2665, DOI: 10.1007/s10545-005-0493-z
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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