Title:
COMPOUNDS, RELATED COMPOSITIONS, CATALYSTS, ELECTROCHEMICAL CELLS, FUEL CELLS, THEIR PREPARATION AND THEIR USES
Document Type and Number:
WIPO Patent Application WO/2017/214546
Kind Code:
A1
Abstract:
In some embodiments, this application relates to inventive compounds (e.g.. Formula (I), Formula (II), thiosemicarbazones and/or thiosemicarbazones and then metal (e.g..zinc, cobalt, nickel, or copper) complexes, and extended structures thereof), methods for preparation of the inventive compounds, compositions comprising the inventive compounds (e.g., anode, cathodes, catalysts (e.g., electrocatalysts), glassy carbon electrodes, carbon paste electrodes, covalently modified carbon (e.g., modified graphene)), electrochemical cells comprising compositions that comprise one or more inventive compounds, fuel cells comprising compositions that comprise one or more inventive compounds, uses of one or more inventive compounds to produce H2 (e.g., via an electrochemical cell), and uses of one or more inventive compounds to create energy from H2 (e.g., via a fuel cell). Additional embodiments of the invention are also discussed herein.
Inventors:
GRAPPERHAUS CRAIG A (US)
BUCHANAN ROBERT M (US)
HADDAD ANDREW Z (US)
BUCHANAN ROBERT M (US)
HADDAD ANDREW Z (US)
Application Number:
PCT/US2017/036815
Publication Date:
December 14, 2017
Filing Date:
June 09, 2017
Export Citation:
Assignee:
UNIV LOUISVILLE RES FOUND INC (US)
International Classes:
C07F3/06
Domestic Patent References:
| WO2010066010A1 | 2010-06-17 |
Other References:
STEFANI CHRISTIAN ET AL: "Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 152, 17 August 2015 (2015-08-17), pages 20 - 37, XP029338706, ISSN: 0162-0134, DOI: 10.1016/J.JINORGBIO.2015.08.010
VIJAYAN PARANTHAMAN ET AL: "Toward a new avenue in ruthenium-sulphur chemistry of binuclear[mu]-sulphido bridged ([mu]-S)2complexes having Ru2S2core: Targeted synthesis, crystal structure, biomolecules interaction and theirin vitroanticancer activities", INORGANICA CHIMICA ACTA, ELSEVIER BV, NL, vol. 453, 14 September 2016 (2016-09-14), pages 596 - 617, XP029775838, ISSN: 0020-1693, DOI: 10.1016/J.ICA.2016.09.024
ANDREW R. COWLEY ET AL: "Copper Complexes of Thiosemicarbazone-Pyridylhydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals", INORGANIC CHEMISTRY, vol. 45, no. 2, 1 January 2006 (2006-01-01), pages 496 - 498, XP055071414, ISSN: 0020-1669, DOI: 10.1021/ic0514492
WINKELMANN E ET AL: "Anticoccidial activity of dithiosemicarbazones", ARZNEIMITTEL FORSCHUNG. DRUG RESEA, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 27, no. 5, 1 January 1977 (1977-01-01), pages 950 - 967, XP009160332, ISSN: 0004-4172
GALLUCCI R., J.CHEM.ENG.DATA, vol. 27, 1 January 1982 (1982-01-01), pages 217 - 219, XP002772464
HUETING R. ET AL: "Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides", DALTON TRANSACTIONS, vol. 39, 3 March 2010 (2010-03-03), pages 3620 - 3632, XP002772465
CALATAYUD D ET AL: "Complexes of group 12 metals containing a hybrid thiosemicarbazone-pyridylhydrazone ligand", INORGANICA CHIMICA ACTA, vol. 381, 20 October 2011 (2011-10-20), pages 150 - 161, XP002772466
CALATAYUD D ET AL: "A fluorescent dissymmetric thiosemicarbazone ligand containing a hydrazone quinoline arm and its complexes with cadmium and mercury", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 7 November 2012 (2012-11-07), pages 80 - 90, XP002772467
STRAISTARI T ET AL: "A thiosemicarbazone-Nickel(II) complex as efficient electrocatalyst for hydrogen evolution", CHEMCATCHEM, vol. 9, 22 November 2016 (2016-11-22), pages 2262 - 2268, XP002772468
MCKONE ET AL: "Earth-abundant hydrogen evolution electrocatalysts", CHEMICAL SCIENCE, vol. 5, 5 November 2013 (2013-11-05), pages 865 - 878, XP002772469
APPEL; HELM, ACS CATAL., vol. 4, 2014, pages 630 - 633
ACS CATAL., vol. 4, 2014, pages 630 - 633
BETTS ET AL., ANGEW. CHEM. INT. ED., vol. 44, 2008, pages 8416 - 8419
CHRISTLIEB ET AL., DALTON TRANS., 2007, pages 5043 - 5054
LEE, INORG. CHEM., vol. 56, 2017, pages 1988 - 1998
VIJAYAN PARANTHAMAN ET AL: "Toward a new avenue in ruthenium-sulphur chemistry of binuclear[mu]-sulphido bridged ([mu]-S)2complexes having Ru2S2core: Targeted synthesis, crystal structure, biomolecules interaction and theirin vitroanticancer activities", INORGANICA CHIMICA ACTA, ELSEVIER BV, NL, vol. 453, 14 September 2016 (2016-09-14), pages 596 - 617, XP029775838, ISSN: 0020-1693, DOI: 10.1016/J.ICA.2016.09.024
ANDREW R. COWLEY ET AL: "Copper Complexes of Thiosemicarbazone-Pyridylhydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals", INORGANIC CHEMISTRY, vol. 45, no. 2, 1 January 2006 (2006-01-01), pages 496 - 498, XP055071414, ISSN: 0020-1669, DOI: 10.1021/ic0514492
WINKELMANN E ET AL: "Anticoccidial activity of dithiosemicarbazones", ARZNEIMITTEL FORSCHUNG. DRUG RESEA, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 27, no. 5, 1 January 1977 (1977-01-01), pages 950 - 967, XP009160332, ISSN: 0004-4172
GALLUCCI R., J.CHEM.ENG.DATA, vol. 27, 1 January 1982 (1982-01-01), pages 217 - 219, XP002772464
HUETING R. ET AL: "Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides", DALTON TRANSACTIONS, vol. 39, 3 March 2010 (2010-03-03), pages 3620 - 3632, XP002772465
CALATAYUD D ET AL: "Complexes of group 12 metals containing a hybrid thiosemicarbazone-pyridylhydrazone ligand", INORGANICA CHIMICA ACTA, vol. 381, 20 October 2011 (2011-10-20), pages 150 - 161, XP002772466
CALATAYUD D ET AL: "A fluorescent dissymmetric thiosemicarbazone ligand containing a hydrazone quinoline arm and its complexes with cadmium and mercury", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 7 November 2012 (2012-11-07), pages 80 - 90, XP002772467
STRAISTARI T ET AL: "A thiosemicarbazone-Nickel(II) complex as efficient electrocatalyst for hydrogen evolution", CHEMCATCHEM, vol. 9, 22 November 2016 (2016-11-22), pages 2262 - 2268, XP002772468
MCKONE ET AL: "Earth-abundant hydrogen evolution electrocatalysts", CHEMICAL SCIENCE, vol. 5, 5 November 2013 (2013-11-05), pages 865 - 878, XP002772469
APPEL; HELM, ACS CATAL., vol. 4, 2014, pages 630 - 633
ACS CATAL., vol. 4, 2014, pages 630 - 633
BETTS ET AL., ANGEW. CHEM. INT. ED., vol. 44, 2008, pages 8416 - 8419
CHRISTLIEB ET AL., DALTON TRANS., 2007, pages 5043 - 5054
LEE, INORG. CHEM., vol. 56, 2017, pages 1988 - 1998
Attorney, Agent or Firm:
GUTTMAN, Harry J. (US)
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