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Title:
COMPOUNDS TARGETING MUTANT OF P53
Document Type and Number:
WIPO Patent Application WO/2023/016434
Kind Code:
A1
Abstract:
Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.

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Inventors:
LI SUJING (CN)
LI AMIN (CN)
ZHENG QIAN (CN)
DANG CHAOJIE (CN)
FAN XINRUI (CN)
LONG WEI (CN)
WANG YANPING (CN)
Application Number:
PCT/CN2022/111050
Publication Date:
February 16, 2023
Filing Date:
August 09, 2022
Export Citation:
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Assignee:
JACOBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D333/66; A61K31/381; A61P35/00; C07D409/12; C07D419/14
Domestic Patent References:
WO2021061643A12021-04-01
WO2017143291A12017-08-24
WO2021262484A12021-12-30
WO2021262541A12021-12-30
WO2021262483A12021-12-30
WO2015178955A12015-11-26
Foreign References:
CN109836434A2019-06-04
Other References:
DATABASE REGISTRY ANONYMOUS : "2-Propenoic acid, 3-(7-amino-2-fluorobenzo[b]thien-3-yl)- (CA INDEX NAME)", XP093035158, retrieved from STN
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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