Title:
COMPOUNDS THAT ACT TO MODULATE INSECT GROWTH AND METHODS AND SYSTEMS FOR IDENTIFYING SUCH COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2005022167
Kind Code:
A3
Abstract:
Disclosed are methods and systems for screening for compounds that act to modulate insect growth. Bioassays including cell culture and/or transgenic insects engineered with various components of the ecdysoid receptor (EcR) and/or the farsenoid-X receptor (RXR) systems to identify compounds that act as insecticides and/or hormone receptor activators are described. Also described are compounds, and compositions, identified as being putative insecticides based upon their ability to activate EcR and/or FXR mediated transcription.
Inventors:
HENRICH VINCENT C (US)
WEINBERGER CARY ALAN (US)
WEINBERGER CARY ALAN (US)
Application Number:
PCT/US2004/028113
Publication Date:
October 06, 2005
Filing Date:
August 27, 2004
Export Citation:
Assignee:
UNIV NORTH CAROLINA AT GREENSB (US)
HENRICH VINCENT C (US)
WEINBERGER CARY ALAN (US)
HENRICH VINCENT C (US)
WEINBERGER CARY ALAN (US)
International Classes:
A01N53/00; A01N61/00; C12N15/11; C12Q1/68; G01N33/68; G01N33/74; (IPC1-7): C12Q1/68; A01N53/00; C12N15/11; G01N33/68
Domestic Patent References:
| WO1999036520A1 | 1999-07-22 | |||
| WO2001070816A2 | 2001-09-27 |
Other References:
DELA CRUZ FERNANDO ET AL: "Drosophila ecdysone receptor functions as a constitutive activator in yeast", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 62, no. 4, July 1997 (1997-07-01), pages 353 - 359, XP002317821, ISSN: 0960-0760
ARBEITMAN MICHELLE N ET AL: "Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer", CELL, vol. 101, no. 1, 31 March 2000 (2000-03-31), pages 67 - 77, XP002317822, ISSN: 0092-8674
MARTINEZ A ET AL: "Transcriptional activation of the cloned Heliothis virescens (Lepidoptera) ecdysone receptor (HvEcR) by muristerone A", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD, GB, vol. 29, no. 10, 1999, pages 915 - 930, XP002904046, ISSN: 0965-1748
SAEZ ENRIQUE ET AL: "Identification of ligands and coligands for the ecdysone-regulated gene switch", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, no. 26, 19 December 2000 (2000-12-19), pages 14512 - 14517, XP002317823, ISSN: 0027-8424
ZHANG Y ET AL: "NATURAL STRUCTURAL VARIANTS OF THE NUCLEAR RECEPTOR FARNESOID X RECEPTOR AFFECT TRANSCRIPTIONAL ACTIVATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 278, no. 1, 3 January 2003 (2003-01-03), pages 104 - 110, XP001152959, ISSN: 0021-9258
DINAN LAURENCE ET AL: "Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor", BIOCHEMICAL JOURNAL, vol. 327, no. 3, 1 November 1997 (1997-11-01), pages 643 - 650, XP002317824, ISSN: 0264-6021
HENRICH VINCENT C ET AL: "Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system.", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 33, no. 12, December 2003 (2003-12-01), pages 1239 - 1247, XP008042824, ISSN: 0965-1748
ARBEITMAN MICHELLE N ET AL: "Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer", CELL, vol. 101, no. 1, 31 March 2000 (2000-03-31), pages 67 - 77, XP002317822, ISSN: 0092-8674
MARTINEZ A ET AL: "Transcriptional activation of the cloned Heliothis virescens (Lepidoptera) ecdysone receptor (HvEcR) by muristerone A", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD, GB, vol. 29, no. 10, 1999, pages 915 - 930, XP002904046, ISSN: 0965-1748
SAEZ ENRIQUE ET AL: "Identification of ligands and coligands for the ecdysone-regulated gene switch", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, no. 26, 19 December 2000 (2000-12-19), pages 14512 - 14517, XP002317823, ISSN: 0027-8424
ZHANG Y ET AL: "NATURAL STRUCTURAL VARIANTS OF THE NUCLEAR RECEPTOR FARNESOID X RECEPTOR AFFECT TRANSCRIPTIONAL ACTIVATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 278, no. 1, 3 January 2003 (2003-01-03), pages 104 - 110, XP001152959, ISSN: 0021-9258
DINAN LAURENCE ET AL: "Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor", BIOCHEMICAL JOURNAL, vol. 327, no. 3, 1 November 1997 (1997-11-01), pages 643 - 650, XP002317824, ISSN: 0264-6021
HENRICH VINCENT C ET AL: "Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system.", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 33, no. 12, December 2003 (2003-12-01), pages 1239 - 1247, XP008042824, ISSN: 0965-1748
Download PDF:
Previous Patent: PROTEIN CRYSTALLINE STATE JUDGING METHOD AND ITS SYSTEM
Next Patent: HEMATOLOGICAL ANALYZER ON WHOLE BLOOD WITH STIRRING DEVICE
Next Patent: HEMATOLOGICAL ANALYZER ON WHOLE BLOOD WITH STIRRING DEVICE